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Karanam Balasubramanyam

Explore the profile of Karanam Balasubramanyam including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 732
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Recent Articles
1.
Karthigeyan D, Siddhanta S, Kishore A, Perumal S, Agren H, Sudevan S, et al.
Proc Natl Acad Sci U S A . 2014 Jun; 111(29):10416-21. PMID: 24972791
We demonstrate the use of surface-enhanced Raman spectroscopy (SERS) as an excellent tool for identifying the binding site of small molecules on a therapeutically important protein. As an example, we...
2.
Selvi B, Batta K, Kishore A, Mantelingu K, Varier R, Balasubramanyam K, et al.
J Biol Chem . 2009 Dec; 285(10):7143-52. PMID: 20022955
Methylation of the arginine residues of histones by methyltransferases has important consequences for chromatin structure and gene regulation; however, the molecular mechanism(s) of methyltransferase regulation is still unclear, as is...
3.
Zheng Y, Balasubramanyam K, Cebrat M, Buck D, Guidez F, Zelent A, et al.
J Am Chem Soc . 2005 Dec; 127(49):17182-3. PMID: 16332055
This paper describes the first potent and selective p300 histone acetyltransferase (HAT) inhibitor which is effective in live cells. This compound 7 is a coenzyme A analogue conjugated to a...
4.
Davidson S, Townsend P, Carroll C, Yurek-George A, Balasubramanyam K, Kundu T, et al.
Chembiochem . 2004 Dec; 6(1):162-70. PMID: 15593114
Anacardic acid is an alkylsalicylic acid obtained from cashew-nut-shell liquid, and is a potent inhibitor of p300 histone acetyl-transferase (HAT) activity. We have used anacardic acid to prevent the induction...
5.
Balasubramanyam K, Varier R, Altaf M, Swaminathan V, Siddappa N, Ranga U, et al.
J Biol Chem . 2004 Sep; 279(49):51163-71. PMID: 15383533
Acetylation of histones and non-histone proteins is an important post-translational modification involved in the regulation of gene expression in eukaryotes and all viral DNA that integrates into the human genome...
6.
Varier R, Swaminathan V, Balasubramanyam K, Kundu T
Biochem Pharmacol . 2004 Aug; 68(6):1215-20. PMID: 15313419
Histone acetylation is a diagnostic feature of transcriptionally active chromatin. The group of enzymes, histone acetyltransferases (HATs), involved in this crucial step of gene regulation, covalently modifies the N-terminal lysine...
7.
Balasubramanyam K, Altaf M, Varier R, Swaminathan V, Ravindran A, Sadhale P, et al.
J Biol Chem . 2004 May; 279(32):33716-26. PMID: 15155757
Histone acetylation is a diagnostic feature of transcriptionally active genes. The proper recruitment and function of histone acetyltransferases (HATs) and deacetylases (HDACs) are key regulatory steps for gene expression and...
8.
Balasubramanyam K, Swaminathan V, Ranganathan A, Kundu T
J Biol Chem . 2003 Mar; 278(21):19134-40. PMID: 12624111
Histone acetyltransferases (HATs) are a group of enzymes that play a significant role in the regulation of gene expression. These enzymes covalently modify the N-terminal lysine residues of histones by...