Hayley L Rein
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Explore the profile of Hayley L Rein including associated specialties, affiliations and a list of published articles.
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9
Citations
54
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Recent Articles
1.
Hengel S, Oppenheimer K, Smith C, Schaich M, Rein H, Martino J, et al.
Nat Commun
. 2024 Aug;
15(1):7197.
PMID: 39169038
Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a...
2.
Hengel S, Oppenheimer K, Smith C, Schaich M, Rein H, Martino J, et al.
bioRxiv
. 2024 Feb;
PMID: 38405734
Templated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a...
3.
Rein H, Bernstein K
DNA Repair (Amst)
. 2024 Feb;
135:103644.
PMID: 38330859
In the 20+ years since the discovery of RAD51C, scientists have been perplexed as to how missense variants in this tumor suppressor gene impacts its function and pathogenicity. With a...
4.
Rein H, Bernstein K
DNA Repair (Amst)
. 2023 Aug;
130:103563.
PMID: 37651978
For many individuals harboring a variant of uncertain functional significance (VUS) in a homologous recombination (HR) gene, their risk of developing breast and ovarian cancer is unknown. Integral to the...
5.
Prakash R, Rawal Y, Sullivan M, Grundy M, Bret H, Mihalevic M, et al.
Proc Natl Acad Sci U S A
. 2022 Sep;
119(38):e2202727119.
PMID: 36099300
Mutations in homologous recombination (HR) genes, including , , and the RAD51 paralog , predispose to tumorigenesis and sensitize cancers to DNA-damaging agents and poly(ADP ribose) polymerase inhibitors. However, ∼800...
6.
Rein H, Bernstein K, Baldock R
Curr Opin Genet Dev
. 2021 Jul;
71:86-91.
PMID: 34311385
RAD51 paralog gene mutations are observed in both hereditary breast and ovarian cancers. Classically, defects in RAD51 paralog function are associated with homologous recombination (HR) deficiency and increased genomic instability....
7.
Prakash R, Sandoval T, Morati F, Zagelbaum J, Lim P, White T, et al.
Nat Commun
. 2021 Jul;
12(1):4255.
PMID: 34253720
Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different...
8.
Jiang Z, Lai Y, Beaver J, Tsegay P, Zhao M, Horton J, et al.
Cells
. 2020 Jan;
9(1).
PMID: 31963223
DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek...
9.
Ren Y, Lai Y, Laverde E, Lei R, Rein H, Liu Y
PLoS One
. 2017 May;
12(5):e0177299.
PMID: 28475635
Trinucleotide repeat (TNR) instability is associated with human neurodegenerative diseases and cancer. Recent studies have pointed out that DNA base excision repair (BER) mediated by DNA polymerase β (pol β)...