Kandarp M Dave
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Explore the profile of Kandarp M Dave including associated specialties, affiliations and a list of published articles.
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15
Citations
201
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0
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Recent Articles
1.
Jhaveri J, Khare P, Pinky P, Kamte Y, Chandwani M, Milosevic J, et al.
Eur J Pharm Biopharm
. 2024 Sep;
204:114500.
PMID: 39303949
Extracellular vesicles (EVs) are an emerging class of drug carriers and are primarily reported to be internalized into recipient cells via a combination of endocytic routes such as clathrin-mediated, caveolae-mediated...
2.
Dave K, Venna V, Rao K, Stolz D, Brady B, Quaicoe V, et al.
J Control Release
. 2024 Jul;
373:803-822.
PMID: 39084466
Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain endothelial cells (BECs) results in long-term neurological dysfunction post-stroke. We previously reported data from a pilot study where intravenous administration of...
3.
Dave K, Venna V, Rao K, Stolz D, Brady B, Quaicoe V, et al.
bioRxiv
. 2024 Jan;
PMID: 38293207
Ischemic stroke-induced mitochondrial dysfunction in the blood-brain barrier-forming brain endothelial cells ( ) results in long-term neurological dysfunction post-stroke. We previously data from a pilot study where administration of human...
4.
Dave K, Stolz D, Manickam D
Expert Opin Drug Deliv
. 2023 Nov;
20(12):1769-1788.
PMID: 37921194
Introduction: Ischemic stroke-induced mitochondrial dysfunction in brain endothelial cells () leads to breakdown of the blood-brain barrier () causing long-term neurological dysfunction. Restoration of mitochondrial function in injured BECs is...
5.
Dave K, Zhao W, Hoover C, DSouza A, Manickam D
AAPS PharmSciTech
. 2023 Feb;
24(2):63.
PMID: 36759375
No abstract available.
6.
Dave K, Stolz D, Venna V, Quaicoe V, Maniskas M, Reynolds M, et al.
J Control Release
. 2023 Jan;
354:368-393.
PMID: 36642252
Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain barrier (BBB). We harnessed the innate mitochondrial load of BEC-derived extracellular vesicles (EVs) and...
7.
Dave K, Dobbins D, Farinelli M, Sullivan A, Milosevic J, Stolz D, et al.
Cell Mol Bioeng
. 2022 Nov;
15(5):367-389.
PMID: 36444353
Introduction: Extracellular vesicles (EVs) are promising carriers for the delivery of biotherapeutic cargo such as RNA and proteins. We have previously demonstrated that the innate EV mitochondria in microvesicles (MVs),...
8.
Khare P, Dave K, Kamte Y, Manoharan M, ODonnell L, Manickam D
AAPS J
. 2021 Dec;
24(1):8.
PMID: 34873640
Lipidoid nanoparticles (LNPs) are the delivery platform in Onpattro, the first FDA-approved siRNA drug. LNPs are also the carriers in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While these applications...
9.
DSouza A, Burch A, Dave K, Sreeram A, Reynolds M, Dobbins D, et al.
J Control Release
. 2021 Aug;
338:505-526.
PMID: 34450196
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer polarized mitochondria to recipient...
10.
DSouza A, Dave K, Stetler R, Manickam D
Adv Drug Deliv Rev
. 2021 Jan;
171:332-351.
PMID: 33497734
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier (BBB) are emerging...