Kaloyan M Tsanov
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Explore the profile of Kaloyan M Tsanov including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Zhao X, Liu B, William W, Tsanov K, Ho Y, Barriga F, et al.
J Thorac Oncol
. 2024 Dec;
PMID: 39725169
Introduction: Copy-number (CN) loss of chromosome 9p, or parts thereof, impair immune response and confer ICT resistance by direct elimination of immune-regulatory genes on this arm, notably IFNγ genes at...
2.
Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov K, et al.
Immunity
. 2024 Nov;
57(12):2879-2894.e11.
PMID: 39577413
To thrive, cancer cells must navigate acute inflammatory signaling accompanying oncogenic transformation, such as via overexpression of repeat elements. We examined the relationship between immunostimulatory repeat expression, tumor evolution, and...
3.
Tsanov K, Barriga F, Ho Y, Alonso-Curbelo D, Livshits G, Koche R, et al.
bioRxiv
. 2024 Apr;
PMID: 38562717
Driver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations...
4.
Leibold J, Tsanov K, Amor C, Ho Y, Sanchez-Rivera F, Feucht J, et al.
Nat Cancer
. 2024 Jan;
5(2):315-329.
PMID: 38177458
Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of...
5.
Sun S, Hong J, You E, Tsanov K, Chacon-Barahona J, Di Gioacchino A, et al.
bioRxiv
. 2023 Jun;
PMID: 37292765
Overexpression of repetitive elements is an emerging hallmark of human cancers . Diverse repeats can mimic viruses by replicating within the cancer genome through retrotransposition, or presenting pathogen-associated molecular patterns...
6.
Schworer S, Cimino F, Ros M, Tsanov K, Ng C, Lowe S, et al.
Cancer Res
. 2023 Mar;
83(10):1596-1610.
PMID: 36912618
Significance: Hypoxia in the tumor microenvironment of pancreatic cancer potentiates the cytokine-induced inflammatory CAF phenotype and promotes tumor growth. See related commentary by Fuentes and Taniguchi, p. 1560.
7.
Barriga F, Tsanov K, Ho Y, Sohail N, Zhang A, Baslan T, et al.
Nat Cancer
. 2022 Nov;
3(11):1367-1385.
PMID: 36344707
The most prominent homozygous deletions in cancer affect chromosome 9p21.3 and eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis. Half of 9p21.3 deletions, however, also encompass a type...
8.
Baslan T, Morris 4th J, Zhao Z, Reyes J, Ho Y, Tsanov K, et al.
Nature
. 2022 Aug;
608(7924):795-802.
PMID: 35978189
Although p53 inactivation promotes genomic instability and presents a route to malignancy for more than half of all human cancers, the patterns through which heterogenous TP53 (encoding human p53) mutant...
9.
Sanchez-Rivera F, Diaz B, Kastenhuber E, Schmidt H, Katti A, Kennedy M, et al.
Nat Biotechnol
. 2022 Feb;
40(6):862-873.
PMID: 35165384
Base editing can be applied to characterize single nucleotide variants of unknown function, yet defining effective combinations of single guide RNAs (sgRNAs) and base editors remains challenging. Here, we describe...
10.
Missios P, Lummertz da Rocha E, Pearson D, Philipp J, Aleman M, Pirouz M, et al.
J Clin Invest
. 2021 Nov;
131(22).
PMID: 34779407
High expression of LIN28B is associated with aggressive malignancy and poor survival. Here, probing MYCN-amplified neuroblastoma as a model system, we showed that LIN28B expression was associated with enhanced cell...