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Kaitlyn Tkachuk

Explore the profile of Kaitlyn Tkachuk including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 251
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Recent Articles
1.
Berndt S, Vijai J, Benavente Y, Camp N, Nieters A, Wang Z, et al.
Leukemia . 2023 Sep; 37(10):2142. PMID: 37666943
No abstract available.
2.
Berndt S, Vijai J, Benavente Y, Camp N, Nieters A, Wang Z, et al.
Leukemia . 2022 Oct; 36(12):2835-2844. PMID: 36273105
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover...
3.
Kahn R, Ahsan M, Chapman-Davis E, Holcomb K, Nitecki R, Rauh-Hain J, et al.
Fam Cancer . 2022 Oct; 22(2):127-133. PMID: 36207653
Cascade testing for familial cancer syndromes has historically been difficult to execute. As part of a facilitated cascade testing pathway, we evaluated barriers to completion of cascade testing. Our previously...
4.
Song X, Ru M, Steinsnyder Z, Tkachuk K, Kopp R, Sullivan J, et al.
Cancer Epidemiol Biomarkers Prev . 2022 May; 31(7):1466-1472. PMID: 35511739
Background: A previous genome-wide association study identified several loci with genetic variants associated with prostate cancer survival time in two cohorts from Sweden. Whether these variants have an effect in...
5.
Mukherjee S, Bandlamudi C, Hellmann M, Kemel Y, Drill E, Rizvi H, et al.
Cancer Epidemiol Biomarkers Prev . 2022 Apr; 31(7):1450-1459. PMID: 35477182
Background: The genetic factors that modulate risk for developing lung cancer have not been fully defined. Here, we sought to determine the prevalence and clinical significance of germline pathogenic/likely pathogenic...
6.
Liu Y, Cadoo K, Mukherjee S, Khurram A, Tkachuk K, Kemel Y, et al.
Cancer Epidemiol Biomarkers Prev . 2021 Nov; 31(2):362-371. PMID: 34810208
Background: Cancer survivors are developing more subsequent tumors. We sought to characterize patients with multiple (≥2) primary cancers (MPC) to assess associations and genetic mechanisms. Methods: Patients were prospectively consented...
7.
Setton J, Selenica P, Mukherjee S, Shah R, Pecorari I, McMillan B, et al.
NPJ Breast Cancer . 2021 Oct; 7(1):135. PMID: 34635660
Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting...
8.
Stadler Z, Maio A, Chakravarty D, Kemel Y, Sheehan M, Salo-Mullen E, et al.
J Clin Oncol . 2021 Jun; 39(24):2698-2709. PMID: 34133209
Purpose: Tumor mutational profiling is increasingly performed in patients with advanced cancer. We determined the extent to which germline mutation profiling guides therapy selection in patients with advanced cancer. Methods:...
9.
Topka S, Steinsnyder Z, Ravichandran V, Tkachuk K, Kemel Y, Bandlamudi C, et al.
Clin Cancer Res . 2020 Nov; 27(7):1997-2010. PMID: 33199492
Purpose: Nucleotide excision repair (NER) gene alterations constitute potential cancer therapeutic targets. We explored the prevalence of NER gene alterations across cancers and putative therapeutic strategies targeting these vulnerabilities. Experimental...
10.
Fiala E, Ortiz M, Kennedy J, Glodzik D, Fleischut M, Duffy K, et al.
Cancer . 2020 Apr; 126(13):3114-3121. PMID: 32320050
Background: Constitutional or somatic mosaic epimutations are increasingly recognized as a mechanism of gene dysregulation resulting in cancer susceptibility. Beckwith-Wiedemann syndrome is the cancer predisposition syndrome most commonly associated with...