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Kaitlyn Schaaf

Explore the profile of Kaitlyn Schaaf including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 95
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Recent Articles
1.
Bastarache J, Smith K, Jesse J, Putz N, Meegan J, Bogart A, et al.
Am J Physiol Lung Cell Mol Physiol . 2021 Dec; 322(2):L273-L282. PMID: 34936510
Mouse models of acute lung injury (ALI) have been instrumental for studies of the biological underpinnings of lung inflammation and permeability, but murine models of sepsis generate minimal lung injury....
2.
Crawford C, Dalecki A, Perez M, Schaaf K, Wolschendorf F, Kutsch O
Sci Rep . 2020 Jun; 10(1):8955. PMID: 32488067
Multi-drug resistant Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), has become a worldwide, major health care problem. While initially restricted to clinical settings, drug resistant S. aureus is now one...
3.
Smith S, Schaaf K, Rajabalee N, Wagner F, Duverger A, Kutsch O, et al.
Sci Rep . 2018 Jan; 8(1):902. PMID: 29343725
Differentiation of circulating monocytes into tissue-bound or tissue-resident macrophages is a critical regulatory process affecting host defense and inflammation. However, the regulatory signaling pathways that control the differentiation of monocytes...
4.
Schaaf K, Smith S, Hayley V, Kutsch O, Sun J
J Vis Exp . 2017 Apr; (121). PMID: 28362407
The early drug development process for anti-tuberculosis drugs is hindered by the inefficient translation of compounds with in vitro activity to effectiveness in the clinical setting. This is likely due...
5.
Schaaf K, Smith S, Duverger A, Wagner F, Wolschendorf F, Westfall A, et al.
Sci Rep . 2017 Feb; 7:42101. PMID: 28176854
The ability to suppress host macrophage apoptosis is essential for M. tuberculosis (Mtb) to replicate intracellularly while protecting it from antibiotic treatment. We recently described that Mtb infection upregulated expression...
6.
Schaaf K, Hayley V, Speer A, Wolschendorf F, Niederweis M, Kutsch O, et al.
Assay Drug Dev Technol . 2016 Jun; 14(6):345-54. PMID: 27327048
In the last 40 years, only a single new antituberculosis drug was FDA approved. New tools that improve the drug development process will be essential to accelerate the development of...
7.
Sun J, Schaaf K, Duverger A, Wolschendorf F, Speer A, Wagner F, et al.
Oncotarget . 2016 Mar; 7(13):15394-409. PMID: 27004401
Co-infection with HIV-1 and Mycobacterium tuberculosis (Mtb) is a major public health issue. While some research has described how each pathogen accelerates the course of infection of the other pathogen...
8.
Dalecki A, Malalasekera A, Schaaf K, Kutsch O, Bossmann S, Wolschendorf F
Metallomics . 2016 Mar; 8(4):412-21. PMID: 26935206
The continuous rise of multi-drug resistant pathogenic bacteria has become a significant challenge for the health care system. In particular, novel drugs to treat infections of methicillin-resistant Staphylococcus aureus strains...