Jim Sun
Overview
Explore the profile of Jim Sun including associated specialties, affiliations and a list of published articles.
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30
Citations
832
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Recent Articles
1.
Liang Y, Sun Z, Lu C, Lupien A, Xu Z, Berton S, et al.
Microbiol Spectr
. 2024 Oct;
12(11):e0124624.
PMID: 39361873
(Mtb), the pathogen responsible for tuberculosis (TB), is the leading cause of bacterial disease-related death worldwide. Current antibiotic regimens for the treatment of TB remain dated and suffer from long...
2.
Yu Z, Liang Y, Berton S, Liu L, Zou J, Chen L, et al.
J Med Chem
. 2024 Jul;
67(14):11917-11936.
PMID: 38958057
(Mtb), the infectious agent of tuberculosis (TB), causes over 1.5 million deaths globally every year. Host-directed therapies (HDT) for TB are desirable for their potential to shorten treatment and reduce...
3.
Rajabalee N, Siushansian H, Weerapura M, Berton S, Berbatovci F, Hooks B, et al.
J Leukoc Biol
. 2023 Jul;
114(3):280-298.
PMID: 37403209
The differentiation and activation of macrophages are critical regulatory programs that are central to host inflammation and pathogen defense. However, the transcriptional regulatory pathways involved in these programs are not...
4.
Madden K, El Hamra R, Berton S, Felker J, Alvarez G, Blais A, et al.
Microlife
. 2023 Feb;
4:uqad006.
PMID: 36820061
Tuberculosis, a deadly infectious lung disease caused by (Mtb), remains the leading cause of bacterial disease-related deaths worldwide. Mtb reprograms and disables key antibacterial response pathways, many of which are...
5.
Dabla A, Liang Y, Rajabalee N, Irwin C, Moonen C, Willis J, et al.
mBio
. 2022 Aug;
13(4):e0145622.
PMID: 35924849
Macrophage surface receptors are critical for pathogen defense, as they are the gatekeepers for pathogen entry and sensing, which trigger robust immune responses. TREM2 (triggering receptor expressed on myeloid cells...
6.
Liang Y, Berton S, Reeks C, Sun J
STAR Protoc
. 2022 Jul;
3(3):101575.
PMID: 35880128
Available mouse models for tuberculosis drug susceptibility testing requires using virulent biosafety-level-3 (BSL-3) (Mtb) strains, or attenuated BSL-2 strains that lack virulence genes. Here, we present a BSL-2-compatible mouse model...
7.
Berton S, Chen L, Liang Y, Xu Z, Afriyie-Asante A, Rajabalee N, et al.
Cell Chem Biol
. 2022 Mar;
29(7):1126-1139.e12.
PMID: 35320734
Metal-dependent protein phosphatases (PPMs) have essential roles in a variety of cellular processes, including inflammation, proliferation, differentiation, and stress responses, which are intensively investigated in cancer and metabolic diseases. Targeting...
8.
Madden K, Liang Y, Rajabalee N, Alvarez G, Sun J
Infect Immun
. 2022 Mar;
90(5):e0052221.
PMID: 35311579
Tuberculosis (TB) remains the leading cause of bacterial disease-related death and is among the top 10 overall causes of death worldwide. The complex nature of this infectious lung disease has...
9.
Afriyie-Asante A, Dabla A, Dagenais A, Berton S, Smyth R, Sun J
Front Immunol
. 2021 Nov;
12:742370.
PMID: 34745115
Tuberculosis is a deadly, contagious respiratory disease that is caused by the pathogenic bacterium (Mtb). Mtb is adept at manipulating and evading host immunity by hijacking alveolar macrophages, the first...
10.
Smyth R, Sun J
Front Immunol
. 2021 Jul;
12:702142.
PMID: 34305942
The global antimicrobial resistance crisis poses a significant threat to humankind in the coming decades. Challenges associated with the development of novel antibiotics underscore the urgent need to develop alternative...