Kai Hell
Overview
Explore the profile of Kai Hell including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
1731
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Recent Articles
1.
Badrie S, Hell K, Mokranjac D
EMBO Rep
. 2025 Jan;
26(4):911-928.
PMID: 39753782
Import and assembly of mitochondrial proteins into multimeric complexes are essential for cellular function. Yet, many steps of these processes and the proteins involved remain unknown. Here, we identify a...
2.
Specht S, Liedgens L, Duarte M, Stiegler A, Wirth U, Eberhardt M, et al.
Redox Biol
. 2018 Jan;
15:363-374.
PMID: 29310075
Mia40/CHCHD4 and Erv1/ALR are essential for oxidative protein folding in the mitochondrial intermembrane space of yeast and mammals. In contrast, many protists, including important apicomplexan and kinetoplastid parasites, lack Mia40....
3.
Schusdziarra C, Blamowska M, Azem A, Hell K
Hum Mol Genet
. 2012 Dec;
22(7):1348-57.
PMID: 23263864
Loss of expression of the methylation-controlled J gene, MCJ (DNAJC15), is observed in cases of several tumors and plays a crucial role in the chemoresistance of ovarian cancer cells. Aside...
4.
Eckers E, Petrungaro C, Gross D, Riemer J, Hell K, Deponte M
J Biol Chem
. 2012 Dec;
288(4):2676-88.
PMID: 23233680
Mia40 and the sulfhydryl:cytochrome c oxidoreductase Erv1/ALR are essential for oxidative protein import into the mitochondrial intermembrane space in yeast and mammals. Although mitochondrial protein import is functionally conserved in...
5.
Blamowska M, Neupert W, Hell K
J Cell Biol
. 2012 Sep;
199(1):125-35.
PMID: 23007651
Chaperones mediate protein folding and prevent deleterious protein aggregation in the cell. However, little is known about the biogenesis of chaperones themselves. In this study, we report on the biogenesis...
6.
Gross D, Burgard C, Reddehase S, Leitch J, Culotta V, Hell K
Mol Biol Cell
. 2011 Aug;
22(20):3758-67.
PMID: 21865601
The copper chaperone for superoxide dismutase 1 (Ccs1) provides an important cellular function against oxidative stress. Ccs1 is present in the cytosol and in the intermembrane space (IMS) of mitochondria....
7.
Blamowska M, Sichting M, Mapa K, Mokranjac D, Neupert W, Hell K
J Biol Chem
. 2009 Dec;
285(7):4423-31.
PMID: 20007714
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. We have analyzed the interaction of Hep1 with mitochondrial Hsp70 (Ssc1) and the determinants in Ssc1 that...
8.
Deponte M, Hell K
J Biochem
. 2009 Sep;
146(5):599-608.
PMID: 19720617
Proteins of the intermembrane space (IMS) of mitochondria fulfil crucial functions in cellular processes, such as transport of proteins and metal ions, ATP production and apoptotic cell death. All IMS...
9.
Mokranjac D, Sichting M, Popov-celeketic D, Mapa K, Gevorkyan-Airapetov L, Zohary K, et al.
Mol Biol Cell
. 2009 Jan;
20(5):1400-7.
PMID: 19144822
Transport of essentially all matrix and a number of inner membrane proteins is governed, entirely or in part, by N-terminal presequences and requires a coordinated action of the translocases of...
10.
Gevorkyan-Airapetov L, Zohary K, Popov-celeketic D, Mapa K, Hell K, Neupert W, et al.
J Biol Chem
. 2008 Nov;
284(8):4865-72.
PMID: 19017642
The TIM23 complex is the major translocase of the mitochondrial inner membrane responsible for the import of essentially all matrix proteins and a number of inner membrane proteins. Tim23 and...