Kai Breuhahn
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Explore the profile of Kai Breuhahn including associated specialties, affiliations and a list of published articles.
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109
Citations
2868
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Recent Articles
1.
Toth M, Wan S, Schmitt J, Birner P, Wei T, von Bubnoff F, et al.
Int J Mol Sci
. 2025 Jan;
26(2.
PMID: 39859373
The oncogenes yes-associated protein () and transcriptional coactivator with PDZ-binding motif () are potent liver oncogenes. Because gene mutations cannot fully explain their nuclear enrichment, we aim to understand which...
2.
Assal R, Abd El-Bary R, Youness R, Abdelrahman M, Zahran H, Hosny K, et al.
BMC Gastroenterol
. 2024 Sep;
24(1):337.
PMID: 39350070
Background: Proteoglycans are important tumor microenvironment extracellular matrix components. The regulation of key proteoglycans, such as decorin (DCN), by miRNAs has drawn attention since they have surfaced as novel therapeutic...
3.
Wesener M, Weiler S, Bissinger M, Klessinger T, Rose F, Merker S, et al.
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39126118
The Hippo pathway transducers yes-associated protein (YAP) and WW-domain containing transcription regulator 1 (WWTR1/TAZ) are key regulators of liver tumorigenesis, promoting tumor formation and progression. Although the first inhibitors are...
4.
Dropmann A, Alex S, Schorn K, Tong C, Caccamo T, Godoy P, et al.
Biochem Biophys Res Commun
. 2024 Jul;
732:150409.
PMID: 39033550
Introduction: WNT1-inducible signalling pathway protein 1 (WISP1) promotes progression of several tumor entities often correlating with worse prognosis. Here its expression regulation and role in the progression of chronic liver...
5.
Krieg S, Rohde T, Rausch T, Butthof L, Wendler-Link L, Eckert C, et al.
Genome Med
. 2024 Jun;
16(1):83.
PMID: 38886830
Background: Somatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Here, we focused on the identification of specific vulnerabilities for tumors harboring chromosome...
6.
Albrecht T, Rossberg A, Rose F, Breuhahn K, Baumann E, Toth M, et al.
J Clin Pathol
. 2024 May;
PMID: 38749660
Aims: Intrahepatic cholangiocarcinoma (iCCA) is a diagnosis of exclusion that can pose a challenge to the pathologist despite thorough clinical workup. Although several immunohistochemical markers have been proposed for iCCA,...
7.
Tran C, Kersten J, Yan J, Breinig M, Huth T, Poth T, et al.
Gastroenterology
. 2024 Apr;
167(3):522-537.
PMID: 38636680
Background & Aims: High expression of phosphatidylinositol 4-kinase III alpha (PI4KIIIα) correlates with poor survival rates in patients with hepatocellular carcinoma. In addition, hepatitis C virus (HCV) infections activate PI4KIIIα...
8.
Wan S, He Q, Yang Y, Liu F, Zhang X, Guo X, et al.
Cancer Res
. 2024 Mar;
84(11):1872-1888.
PMID: 38471084
Significance: Intracellular SPARC boosts cholesterol availability to fuel invasion and drug resistance in hepatocellular carcinoma, providing a rational approach to improve the treatment of advanced liver cancer.
9.
Liu K, Wehling L, Wan S, Weiler S, Toth M, Ibberson D, et al.
Cell Mol Life Sci
. 2024 Mar;
81(1):115.
PMID: 38436764
Introduction: The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the...
10.
Weiler S, Bissinger M, Rose F, von Bubnoff F, Lutz T, Ori A, et al.
Cancer Lett
. 2024 Jan;
584:216637.
PMID: 38242197
The transcriptional co-activators of the Hippo pathway, YAP and TAZ, are regulated by mechanotransduction, which depends on dynamic actin cytoskeleton remodeling. Here, we identified SEPTIN10 as a novel cytoskeletal protein,...