K W Michael Siu
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Explore the profile of K W Michael Siu including associated specialties, affiliations and a list of published articles.
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144
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2242
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Recent Articles
1.
Fang L, Liu C, Jiang Z, Wang M, Geng K, Xu Y, et al.
Signal Transduct Target Ther
. 2024 Aug;
9(1):218.
PMID: 39174522
Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular pathogenesis. Annexin A1 (ANXA1) is known to inhibit...
2.
Li Y, Lau J, van Wieringen T, Martens J, Berden G, Oomens J, et al.
PLoS One
. 2024 Aug;
19(8):e0308164.
PMID: 39137228
Herein, we explore the generation and characterization of the radical cations of glycylphenylalanylglycine, or [GFG]•+, formed via dissociative electron-transfer reaction from the tripeptide to copper(II) within a ternary complex. A...
3.
Lau J, Hopkinson A, Siu K
J Phys Chem B
. 2024 Jan;
128(2):504-514.
PMID: 38190618
Residue-specific phosphorylation is a protein post-translational modification that regulates cellular functions. Experimental determination of the exact sites of protein phosphorylation provides an understanding of the signaling and processes at work...
4.
Corchis-Scott R, Geng Q, Seth R, Ray R, Beg M, Biswas N, et al.
Microbiol Spectr
. 2021 Oct;
9(2):e0079221.
PMID: 34612693
A wastewater surveillance program targeting a university residence hall was implemented during the spring semester 2021 as a proactive measure to avoid an outbreak of COVID-19 on campus. Over a...
5.
Generation, Characterization, and Dissociation of Radical Cations Derived from Prolyl-glycyl-glycine
Lau J, Esuon F, Berden G, Oomens J, Hopkinson A, Ryzhov V, et al.
J Phys Chem B
. 2021 Jun;
125(23):6121-6129.
PMID: 34097420
Radical cations of an aliphatic tripeptide prolyl-glycyl-glycine (PGG) and its sequence ions [a + H] and [b - H] have been generated by collision-induced dissociation of the [Cu(Phen)(PGG)] complex, where...
6.
Dong N, Spencer D, Quan Q, Le Blanc J, Feng J, Li M, et al.
Anal Chem
. 2020 Jul;
92(15):10768-10776.
PMID: 32628467
We present herein rPTMDetermine, an adaptive and fully automated methodology for validation of the identification of rarely occurring post-translational modifications (PTMs), using a semisupervised approach with a linear discriminant analysis...
7.
Li Y, Li M, Spencer D, Lau J, Martens J, Berden G, et al.
Phys Chem Chem Phys
. 2020 Jun;
22(23):13084-13091.
PMID: 32490449
We report herein the first detailed study of the mechanism of redox reactions occurring during the gas-phase dissociative electron transfer of prototypical ternary [Cu(dien)M]˙ complexes (M, peptide). The two final...
8.
Lesslie M, Lau J, Lawler J, Siu K, Steinmetz V, Maitre P, et al.
Chempluschem
. 2020 Jan;
81(5):444-452.
PMID: 31968776
The formation and investigation of sulfur-based cysteine radicals cationized by a group 1A metal ion or Ag in the gas phase are reported. Gas-phase ion-molecule reactions (IMR) and infrared multiple-photon...
9.
Wang Y, Lau J, Lai C, Hopkinson A, Siu K
J Phys Chem B
. 2019 Nov;
123(48):10192-10201.
PMID: 31693371
[a + H] ions generated from Ln/tripeptide complexes, where Ln = La or Ce, have similar structures to the linear [a] ions but with protonation at both the terminal NH...
10.
Wang Y, Lai C, Lau J, Hopkinson A, Siu K
J Phys Chem B
. 2019 Jun;
123(25):5229-5237.
PMID: 31242740
Structures of [Ce(GGG)] and [Ce(GGG ? H)] have been investigated by DFT calculations. The two lowest-energy structures of the triply charged metal complex have the peptide in either the iminol...