K T Cain
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Explore the profile of K T Cain including associated specialties, affiliations and a list of published articles.
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43
Citations
239
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Recent Articles
1.
Liu Y, Sundberg J, Das S, Carpenter D, Cain K, Michaud E, et al.
Vet Pathol
. 2010 Jan;
47(1):167-76.
PMID: 20080498
Animal models carrying mutations in the hairless (Hr) gene provide a rich resource for study of hair follicle biology. A spontaneous mouse mutant with a phenotype strikingly similar to rhino...
2.
Michaud E, Culiat C, Klebig M, Barker P, Cain K, Carpenter D, et al.
BMC Genomics
. 2005 Nov;
6:164.
PMID: 16300676
Background: Analysis of an allelic series of point mutations in a gene, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, is a valuable method for discovering the full scope of its biological function....
3.
Chittenden L, Lu X, Cacheiro N, Cain K, Generoso W, Bryda E, et al.
Genomics
. 2002 Apr;
79(4):499-504.
PMID: 11944981
In the course of large-scale mutagenesis studies, we discovered a mutant that provides a new mouse model for human autosomal recessive polycystic kidney disease. Animals homozygous for this mutation, T(2;10)67Gso,...
4.
Bishop J, Morris R, Seely J, Hughes L, Cain K, Generoso W
Fundam Appl Toxicol
. 1998 Jan;
40(2):191-204.
PMID: 9441715
Chemicals, by virtue of their varied interactions with biological molecules, are expected to differ in the way they may alter female reproduction. Reproductive toxicity may reflect effects either on the...
5.
Generoso W, Sega G, Lockhart A, Hughes L, Cain K, Cacheiro N, et al.
Mutat Res
. 1996 Dec;
371(3-4):175-83.
PMID: 9008719
The hypothesis that acrylamide induces dominant lethal mutations and heritable translocations in male mice, not through direct adduction, but by conversion to the reactive epoxide, glycidamide, was investigated. Three studies,...
6.
Generoso W, Witt K, Cain K, Hughes L, Cacheiro N, Lockhart A, et al.
Mutat Res
. 1995 Dec;
345(3-4):167-80.
PMID: 8552138
Chemicals used in the treatment of cancer include several that are potent mutagens in a range of in vitro and in vivo assays. For some, genetic effects have also been...
7.
Cacheiro N, Rutledge J, Cain K, Cornett C, Generoso W
Cytogenet Cell Genet
. 1994 Jan;
66(2):139-48.
PMID: 8287687
Reciprocal translocations are readily induced by various physical and chemical mutagens in certain germ-cell stages. Carriers of balanced reciprocal translocations generally exhibit no abnormal phenotypes, except for occasional male sterility,...
8.
Rutledge J, Generoso W, Shourbaji A, Cain K, Gans M, Oliva J
Mutat Res
. 1992 Dec;
296(1-2):167-77.
PMID: 1279403
Results of continuing studies indicate that the mouse zygote and two-cell embryo stages are a window of susceptibility in the experimental induction of congenital anomalies with certain mutagenic agents. The...
9.
Generoso W, Cain K, Cornett C, Frome E
Mutat Res
. 1991 Aug;
249(2):301-10.
PMID: 2072973
In a previous report (Generoso et al., 1985) it was shown that the two hybrid stocks of mice, (C3H/R1 x 101/R1)F1 and (SEC/R1 x C57BL/6)F1, differed in their responses to...
10.
Katoh M, Cain K, Hughes L, Foxworth L, Bishop J, Generoso W
Mutat Res
. 1990 Jun;
230(2):205-17.
PMID: 2374557
For some chemicals, induction of presumed dominant lethal mutations has been observed only in female mice and not in males. In those cases, questions arise as to (1) whether the...