K Sambamurti
Overview
Explore the profile of K Sambamurti including associated specialties, affiliations and a list of published articles.
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35
Citations
883
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Recent Articles
1.
Pappolla M, Matsubara E, Vidal R, Pacheco-Quinto J, Poeggeler B, Zagorski M, et al.
Curr Alzheimer Res
. 2018 Apr;
15(7):637-642.
PMID: 29637859
Background: It has been postulated that inadequate clearance of the amyloid β protein (Aβ) plays an important role in the accumulation of Aβ in sporadic late onset Alzheimer's disease (AD)....
2.
Vasudevaraju P, Govindaraju M, Palanisamy A, Sambamurti K, Rao K
Indian J Med Res
. 2008 Dec;
128(4):545-56.
PMID: 19106446
Exposure to high levels of aluminium (Al) leads to neurofibrillary degeneration and that Al concentration is increased in degenerating neurons in Alzheimer's disease (AD). Nevertheless, the role of Al in...
3.
Vasudevaraju P, Bharathi , Garruto R, Sambamurti K, Rao K
Brain Res Rev
. 2008 Mar;
58(1):136-48.
PMID: 18342372
DNA is a dynamic molecule, the conformation of which plays a major role in biological function. The non-B-form of DNA conformations are reported in the patho-physiology of diseases like Fragile...
4.
Lahiri D, Rogers J, Greig N, Sambamurti K
Curr Pharm Des
. 2004 Nov;
10(25):3111-9.
PMID: 15544501
Alzheimer's disease (AD) is characterized by progressive dementia caused by the loss of the presynaptic markers of the cholinergic system in the brain areas related to memory and learning and...
5.
Lahiri D, Kotwal G, Farlow M, Sima A, Kupsky W, Sarkar F, et al.
Ann N Y Acad Sci
. 2002 Dec;
973:334-9.
PMID: 12485889
Two major pathological hallmarks of Alzheimer's disease (AD) are the senile plaques that are primarily composed of amyloid beta-peptide (Abeta) and neurofibrillary tangles consisting of tau aggregates. Abeta is generated...
6.
Pinnix I, Council J, Roseberry B, Onstead L, Mallender W, Sucic J, et al.
FASEB J
. 2001 Aug;
15(10):1810-2.
PMID: 11481238
No abstract available.
7.
Shaw K, Utsuki T, Rogers J, Yu Q, Sambamurti K, Brossi A, et al.
Proc Natl Acad Sci U S A
. 2001 Jun;
98(13):7605-10.
PMID: 11404470
The reduction in levels of the potentially toxic amyloid-beta peptide (Abeta) has emerged as one of the most important therapeutic goals in Alzheimer's disease. Key targets for this goal are...
8.
Mallender W, Yager D, Onstead L, NICHOLS M, Eckman C, Sambamurti K, et al.
Mol Pharmacol
. 2001 Feb;
59(3):619-26.
PMID: 11179458
The beta-site amyloid precursor protein-cleaving enzyme (BACE) cleaves the amyloid precursor protein to produce the N terminus of the amyloid beta peptide, a major component of the plaques found in...
9.
Haugabook S, Le T, Yager D, Zenk B, Healy B, Eckman E, et al.
FASEB J
. 2000 Dec;
15(1):16-18.
PMID: 11099491
The abnormal accumulation of the amyloid beta protein (Abeta) has been implicated as an early and critical event in the etiology and pathogenesis of Alzheimer's disease (AD). Compounds that reduce...
10.
Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, Eckman C, et al.
J Biol Chem
. 2000 Oct;
276(1):481-7.
PMID: 11035007
Alzheimer's disease is characterized by the deposits of the 4-kDa amyloid beta peptide (A beta). The A beta protein precursor (APP) is cleaved by beta-secretase to generate a C-terminal fragment,...