K R McLeish
Overview
Explore the profile of K R McLeish including associated specialties, affiliations and a list of published articles.
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71
Citations
676
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Recent Articles
1.
Klein J, Buridi A, Coxon P, Rane M, Manning T, Kettritz R, et al.
Cell Signal
. 2001 May;
13(5):335-43.
PMID: 11369515
The present study examined the role of mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3 kinase-stimulated Akt (PI-3K/Akt) in the regulation of constitutive human neutrophil apoptosis by bacterial lipopolysaccharide (LPS) and two...
2.
Blankenship K, Williams J, Lawrence M, McLeish K, Dean W, Arthur J
Am J Physiol Renal Physiol
. 2001 Apr;
280(5):F815-22.
PMID: 11292623
Calcium transport across a monolayer of Madin-Darby canine kidney (MDCK) cells was measured in response to stimulation of the basal surface with calcium-sensing receptor (CaR) agonists. Stimulation of the CaR...
3.
Klein J, Rane M, Scherzer J, Coxon P, Kettritz R, Mathiesen J, et al.
J Immunol
. 2001 Feb;
164(8):4286-91.
PMID: 10754327
Activated neutrophils play an important role in the pathogenesis of sepsis, glomerulonephritis, acute renal failure, and other inflammatory processes. The resolution of neutrophil-induced inflammation relies, in large part, on removal...
4.
Rane M, Coxon P, Powell D, Webster R, Klein J, Pierce W, et al.
J Biol Chem
. 2000 Oct;
276(5):3517-23.
PMID: 11042204
Akt activation requires phosphorylation of Thr(308) and Ser(473) by 3-phosphoinositide-dependent kinase-1 and 2 (PDK1 and PDK2), respectively. While PDK1 has been cloned and sequenced, PDK2 has yet to be identified....
5.
Ward R, Nakamura M, McLeish K
J Biol Chem
. 2000 Sep;
275(47):36713-9.
PMID: 10976103
The respiratory burst of human neutrophils is primed by a number of pro-inflammatory stimuli, including tumor necrosis factor-alpha (TNFalpha) and lipopolysaccharide (LPS); however, the mechanism of priming remains unknown. LPS...
6.
Arthur J, Lawrence M, Payne C, Rane M, McLeish K
Biochem Biophys Res Commun
. 2000 Aug;
275(2):538-41.
PMID: 10964699
The calcium-sensing receptor (CaR) stimulates ERK1 in rat fibroblasts, but its effect on other MAP kinases is not known. We used a model of renal distal tubule, the MDCK cell,...
7.
Coxon P, Rane M, Powell D, Klein J, McLeish K
J Immunol
. 2000 Jun;
164(12):6530-7.
PMID: 10843711
Fc gamma Rs mediate immune complex-induced tissue injury. The hypothesis that Fc gamma RIIa and Fc gamma RIIIb control neutrophil responses by activating mitogen-activated protein kinases was examined. Homotypic and...
8.
Rane M, Prossnitz E, Arthur J, Ward R, McLeish K
Biochem Pharmacol
. 2000 May;
60(2):179-87.
PMID: 10825462
The ability of formyl peptide receptors (FPRs) stably expressed in undifferentiated HL-60 cells to undergo ligand-induced desensitization was compared with their ability in normal and vector-transfected HL-60 cells following granulocyte...
9.
Transplantation, not dialysis, corrects azotemia-dependent priming of the neutrophil oxidative burst
Klein J, McLeish K, Ward R
Am J Kidney Dis
. 1999 Mar;
33(3):483-91.
PMID: 10070912
The oxidative burst of neutrophils from patients with renal failure before the initiation of dialysis is primed for an enhanced response after stimulation by phagocytosis or chemoattractants. This study shows...
10.
McLeish K, Klein J, Coxon P, Head K, Ward R
J Leukoc Biol
. 1998 Dec;
64(6):835-44.
PMID: 9850168
The hypothesis that bacterial phagocytosis by human polymorphonuclear neutrophils (PMNs) stimulates MAPK cascades that regulate respiratory burst activation was tested. Extracellular response kinase (ERK) and p38 kinase, but not c-Jun...