K P Conrad
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Explore the profile of K P Conrad including associated specialties, affiliations and a list of published articles.
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51
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1702
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Recent Articles
1.
Leo C, Jelinic M, Ng H, Marshall S, Novak J, Tare M, et al.
Br J Pharmacol
. 2016 Sep;
174(10):1002-1014.
PMID: 27590257
Linked Articles: This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this...
2.
Founds S, Conley Y, Lyons-Weiler J, Jeyabalan A, Hogge W, Conrad K
Placenta
. 2008 Nov;
30(1):15-24.
PMID: 19027158
Background: Preeclampsia is a pregnancy-specific disorder that remains a leading cause of maternal, fetal and neonatal morbidity and mortality, and is associated with risk for future cardiovascular disease. There are...
3.
Rajakumar A, Michael H, Daftary A, Jeyabalan A, Gilmour C, Conrad K
Placenta
. 2008 Jan;
29(3):290-9.
PMID: 18222538
Hypoxia-inducible transcription factor-1alpha and -2alpha (HIF-alpha) proteins and regulated genes are increased in preeclamptic (PE) placentas. Although placental hypoxia likely stabilizes HIF-alpha proteins, we previously reported that there is also...
4.
Conrad K, Novak J, Danielson L, Kerchner L, Jeyabalan A
Endothelium
. 2005 Jul;
12(1-2):57-62.
PMID: 16036316
A thorough understanding of the renal and cardiovascular adaptations to normal gestation is essential for proper diagnosis and management of hypertensive disorders and renal diseases during pregnancy. Here, we briefly...
5.
Rajakumar A, Doty K, Daftary A, Markovic N, Conrad K
Placenta
. 2005 Jun;
27(4-5):411-21.
PMID: 15955559
The hypoxia inducible transcription factors, HIF-1alpha and -2alpha proteins, are overexpressed in placentae from women with preeclampsia (Biol Reprod 2001;64:499-506; Biol Reprod 2001;64:1019-1020). Normally, these proteins are regulated in an...
6.
Rajakumar A, Brandon H, Daftary A, Ness R, Conrad K
Placenta
. 2004 Sep;
25(10):763-9.
PMID: 15451190
Placentas from women with preeclampsia overexpress the hypoxia-inducible transcription factor proteins, HIF-1alpha and -2alpha (Rajakumar 2001, Biol Reprod 64; p499-506 and p1019-1020). As a first step in evaluating whether HIF-alpha...
7.
Rajakumar A, Doty K, Daftary A, Harger G, Conrad K
Placenta
. 2003 Feb;
24(2-3):199-208.
PMID: 12566247
Pre-eclamptic (PE) placentae overexpress hypoxia inducible transcription factors-1alpha and -2alpha proteins (Biol. Repro. 64: 499-506, 2001; Ibid 1019-1020). Possible explanations include (a) impaired oxygen-dependent reduction, and/or (b) enhanced sensitivity to...
8.
Benyo D, Smarason A, Redman C, Sims C, Conrad K
J Clin Endocrinol Metab
. 2001 Jun;
86(6):2505-12.
PMID: 11397847
It is postulated that inadequate remodeling of the uterine spiral arteries in preeclampsia leads to focal ischemia and generation of inflammatory cytokines, such as tumor necrosis factor (TNF alpha) and...
9.
Novak J, Danielson L, Kerchner L, Sherwood O, Ramirez R, Moalli P, et al.
J Clin Invest
. 2001 Jun;
107(11):1469-75.
PMID: 11390429
Marked vasodilation in the kidney and other nonreproductive organs is one of the earliest maternal adaptations to occur during pregnancy. Despite the recognition of this extraordinary physiology for over four...
10.
Rajakumar A, Whitelock K, Weissfeld L, Daftary A, Markovic N, Conrad K
Biol Reprod
. 2001 Feb;
64(2):499-506.
PMID: 11159352
Transcription factors orchestrate the development of extraembryonic tissues. Because placental hypoxia likely plays an important role in both normal and abnormal placentation, we have been investigating the hypoxia-inducible transcription factors...