K M Huttner
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Explore the profile of K M Huttner including associated specialties, affiliations and a list of published articles.
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21
Citations
492
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Recent Articles
1.
Ouellette A, Darmoul D, Tran D, Huttner K, Yuan J, Selsted M
Infect Immun
. 1999 Nov;
67(12):6643-51.
PMID: 10569786
Paneth cells in crypts of the small intestine express antimicrobial peptides, including alpha-defensins, termed cryptdins in mice. Of the known Paneth cell alpha-defensins, the cryptdin 4 gene is unique, because...
2.
Brogden K, Ackermann M, McCray Jr P, Huttner K
Infect Immun
. 1999 Jul;
67(8):4256-9.
PMID: 10417200
Affinity-purified rabbit polyclonal (PAB96-1) and mouse monoclonal (1G9-1C2) antibodies to synthetic H-DDDDDDD-OH, an antimicrobial anionic peptide (AP) originally isolated from ovine pulmonary surfactant, were prepared and used to assess the...
3.
Huttner K, Bevins C
Pediatr Res
. 1999 Jun;
45(6):785-94.
PMID: 10367766
Mammalian epithelial surfaces are remarkable for their ability to provide critical physiologic functions in the face of frequent microbial challenges. The fact that these mucosal surfaces remain infection-free in the...
4.
Brogden K, Ackermann M, Huttner K
Infect Immun
. 1998 Nov;
66(12):5948-54.
PMID: 9826377
Three small antimicrobial anionic peptides (AP) were originally isolated from an ovine pulmonary surfactant. However, their presence in bronchoalveolar lavage (BAL) fluid and tissues of the respiratory tract is unknown....
5.
Gallo R, Huttner K
J Invest Dermatol
. 1998 Nov;
111(5):739-43.
PMID: 9804331
Antimicrobial peptides are part of the host defense systems of plants, insects, fish, amphibia, birds, and mammals. These small proteins were previously thought of as an evolutionarily ancient system of...
6.
Huttner K, Mahoney M, Diamond G
J Nutr
. 1998 Mar;
128(2 Suppl):297S-299S.
PMID: 9478010
Antimicrobial peptides are abundant components of the innate immune system present in species throughout the plant and animal kingdoms. In mammals, these immune peptides have been localized to epithelial tissues...
7.
Huttner K, Lambeth M, Burkin H, Burkin D, Broad T
Gene
. 1998 Feb;
206(1):85-91.
PMID: 9461419
Antimicrobial peptides are an abundant and diverse component of animal innate immunity. Within mammalian species, defensins and cathelicidins are the two principal antimicrobial peptide families. We identified and sequenced ten...
8.
Huttner K, Kozak C, Bevins C
FEBS Lett
. 1997 Aug;
413(1):45-9.
PMID: 9287114
The cysteine-rich beta-defensin peptides are broad-spectrum bactericidal agents expressed in epithelial and myeloid tissues. The human beta-defensin-1 (hBD-1) gene maps adjacent to the human alpha-defensin cluster and is expressed in...
9.
Brogden K, Ackermann M, Huttner K
Antimicrob Agents Chemother
. 1997 Jul;
41(7):1615-7.
PMID: 9210699
Some inactive precursor proteins, or zymogens, contain small, amino terminus, homopolymeric regions of Asp that neutralize the cationic charge of the active protein during synthesis. After posttranslational cleavage, the anionic...
10.
Mahoney M, Lee A, Huttner K
FEBS Lett
. 1995 Dec;
377(3):519-22.
PMID: 8549789
Cathelin-related genes are characterized by the presence of a prepro sequence which is highly conserved both within and between species. 3' RACE analysis on sheep bone marrow RNA, using a...