K L Longenecker
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Explore the profile of K L Longenecker including associated specialties, affiliations and a list of published articles.
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8
Citations
164
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Recent Articles
1.
Longenecker K, Lewis M, Chikumi H, Gutkind J, Derewenda Z
Structure
. 2001 Jul;
9(7):559-69.
PMID: 11470431
Background: The multidomain PDZ-RhoGEF is one of many known guanine nucleotide exchange factors that upregulate Rho GTPases. PDZ-RhoGEF and related family members play a critical role in a molecular signaling...
2.
Longenecker K, Garrard S, Sheffield P, Derewenda Z
Acta Crystallogr D Biol Crystallogr
. 2001 Apr;
57(Pt 5):679-88.
PMID: 11320308
Crystallization is a unique process that occurs at the expense of entropy, including the conformational entropy of surface residues, which become ordered in crystal lattices during formation of crystal contacts....
3.
Garrard S, Longenecker K, Lewis M, Sheffield P, Derewenda Z
Protein Expr Purif
. 2001 Apr;
21(3):412-6.
PMID: 11281715
Lsc-homology domains are found in several eukaryotic nucleotide exchange factors which act on Rho-family GTPases. They show limited amino acid sequence similarity to RGS proteins, which down-regulate the cellular signaling...
4.
Longenecker K, Zhang B, Derewenda U, Sheffield P, Dauter Z, Parsons J, et al.
J Biol Chem
. 2000 Sep;
275(49):38605-10.
PMID: 10982819
Cellular signaling by small G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydrolysis. The GTPase regulator associated with focal adhesion kinase (Graf) exhibits GAP activity...
5.
Longenecker K, Roach P, Hurley T
Acta Crystallogr D Biol Crystallogr
. 1998 Oct;
54(Pt 3):473-5.
PMID: 9761932
A recombinant form of mammalian casein kinase I delta (CKIdelta) containing the catalytic domain and an auto-inhibitory domain was expressed in Escherichia coli, purified and crystallized. X-ray data were collected...
6.
Longenecker K, Roach P, Hurley T
J Mol Biol
. 1996 Apr;
257(3):618-31.
PMID: 8648628
The three-dimensional structure for the catalytic region of the mammalian protein kinase, casein kinase I delta (CKI delta), has been solved by X-ray crystallography to a resolution of 2.3 A....
7.
Sokol P, Longenecker K, Kachel D, Martin 2nd W
J Pharmacol Exp Ther
. 1993 Apr;
265(1):60-6.
PMID: 8474031
Effective lung repair requires optimal replication of critical cell populations in the lung. Endogenous polyamines such as putrescine, spermidine and spermine play important roles in cell proliferation and differentiation, and...
8.
Zhai L, Graves P, Longenecker K, DePaoli-Roach A, Roach P
Biochem Biophys Res Commun
. 1992 Dec;
189(2):944-9.
PMID: 1472067
The casein kinase I (CKI) family consists of widely distributed monomeric Ser/Thr protein kinases that have a preference for acidic substrates. Four mammalian isoforms are known. A full length cDNA...