K J Kopecky
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Explore the profile of K J Kopecky including associated specialties, affiliations and a list of published articles.
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78
Citations
2093
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Recent Articles
11.
Flinn I, Kopecky K, Foucar M, Head D, Bennett J, Hutchison R, et al.
Blood
. 2000 Oct;
96(9):2981-6.
PMID: 11049974
The nucleoside analogue, pentostatin, has demonstrated high complete response rates and long relapse-free survival times in patients with hairy cell leukemia, a disease that historically had been unresponsive to treatment....
12.
Chauncey T, Rankin C, Anderson J, Chen I, Kopecky K, Godwin J, et al.
Leuk Res
. 2000 Jun;
24(7):567-74.
PMID: 10867130
Older patients with acute myelogenous leukemia (AML) have overexpression of P-glycoprotein (Pgp+), and this has been shown to correlate quantitatively with therapeutic outcome. Since Pgp-mediated efflux of cytotoxic drugs can...
13.
Rimsza L, Kopecky K, Ruschulte J, Chen I, Slovak M, Karanes C, et al.
Leukemia
. 2000 Jun;
14(6):1044-51.
PMID: 10865971
The frequency of acute leukemia in children with constitutional DNA repair defects implicates defective DNA repair in leukemogenesis. Whether sporadic cases of AML also arise from an inherited genetic predisposition...
14.
Zhang F, Gaytan P, Forman S, Kopecky K, Willman C, Appelbaum F, et al.
Genes Chromosomes Cancer
. 2000 Jun;
28(3):318-28.
PMID: 10862038
Multicolor spectral karyotyping allows simultaneous visualization of all human chromosomes and screening for chromosomal rearrangements without a priori knowledge of any abnormalities involved. Based on this potentially increased sensitivity, we...
15.
Crump C, Chen C, Appelbaum F, Kopecky K, Schwartz S, Willman C, et al.
Cancer Epidemiol Biomarkers Prev
. 2000 May;
9(5):457-60.
PMID: 10815689
Individuals with a homozygous deletion of the glutathione S-transferase theta 1 (GSTT1) gene lack GSTT1 enzymatic detoxification of environmental carcinogens by conjugation with glutathione. The GSTT1 gene deletion has been...
16.
Karanes C, Kopecky K, Head D, Grever M, HYNES H, Kraut E, et al.
Leuk Res
. 1999 Sep;
23(9):787-94.
PMID: 10475617
The aim of this study is to determine whether the addition of mitoxantrone to high dose cytarabine improves the outcome of treatment in patients with relapsed or refractory acute myeloid...
17.
Tallman M, Hakimian D, Kopecky K, Wheaton S, Wollins E, Foucar K, et al.
Clin Cancer Res
. 1999 Aug;
5(7):1665-70.
PMID: 10430066
The purine nucleoside analogues 2-chlorodeoxyadenosine (2-CdA) and 2'-deoxycoformycin (2'-DCF) induce complete remission (CR) in the majority of patients with hairy cell leukemia. However, minimal residual disease (MRD) has been detected...
18.
Leith C, Kopecky K, Chen I, Eijdems L, Slovak M, McCONNELL T, et al.
Blood
. 1999 Jul;
94(3):1086-99.
PMID: 10419902
Therapeutic resistance is a major obstacle in the treatment of acute myeloid leukemia (AML). Such resistance has been associated with rapid drug efflux mediated by the multidrug resistance gene 1...
19.
Li Q, Kopecky K, Mohan A, Willman C, Appelbaum F, Weick J, et al.
Clin Cancer Res
. 1999 Jun;
5(5):1077-84.
PMID: 10353741
Estrogen receptor methylation (ERM) is a frequent molecular alteration in adult acute myeloid leukemia (AML). In this study, we sought to determine the clinical characteristics and prognostic significance of ERM...
20.
Hogge D, Willman C, Kreitman R, Berger M, Hall P, Kopecky K, et al.
Blood
. 1998 Jul;
92(2):589-95.
PMID: 9657759
We have previously demonstrated that human granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to a truncated diphtheria toxin (DT388-GMCSF) kills acute myelogenous leukemia (AML) cell lines bearing the GM-CSF receptor. We now...