K H Sprugel
Overview
Explore the profile of K H Sprugel including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
559
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Recent Articles
1.
Grossmann A, Lenox J, Deisher T, Ren H, HUMES J, Kaushansky K, et al.
Blood
. 1996 Nov;
88(9):3363-70.
PMID: 8896401
Severe suppression of the hematopoietic system is a major factor in limiting chemotherapy dose escalation. To determine whether a combination of human recombinant granulocyte colony-stimulating factor (G-CSF) and thrombopoietin (TPO)...
2.
Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice
Grossmann A, Lenox J, Ren H, HUMES J, Forstrom J, Kaushansky K, et al.
Exp Hematol
. 1996 Aug;
24(10):1238-46.
PMID: 8765500
The recent cloning of thrombopoietin (TPO) has allowed us to study its in vivo effects in normal and myelosuppressed mice. Normal Balb/c mice were treated with recombinant human TPO (hTPO)...
3.
Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel K, Broudy V
Exp Hematol
. 1996 Feb;
24(2):265-9.
PMID: 8641351
Thrombopoietin (Tpo), the ligand for the proto-oncogene receptor c-Mpl, increases megakaryocyte size, ploidy, and surface expression of platelet-specific glycoproteins, is inversely related to platelet mass, and is a potent in...
4.
Karr B, Bubak P, Sprugel K, Pavlin E, Engrav L
J Surg Res
. 1995 Dec;
59(6):739-42.
PMID: 8538174
This experiment was undertaken for three purposes: (1) to determine a dose-response curve of acute steroid inhibition of wound contraction in the rat; (2) to confirm the results of our...
5.
McCarty J, Sprugel K, Fox N, Sabath D, Kaushansky K
Blood
. 1995 Nov;
86(10):3668-75.
PMID: 7579332
The activity of the c-Mpl ligand hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bio-assays have shown that blood TPO levels are inversely related to platelet mass. We sought to...
6.
Kaushansky K, Broudy V, Grossmann A, Humes J, Lin N, Ren H, et al.
J Clin Invest
. 1995 Sep;
96(3):1683-7.
PMID: 7657840
Thrombopoietin (TPO), the ligand for the receptor protooncogene c-mpl, has been cloned and shown to be the critical regulator of platelet production. Several features of c-Mpl expression, including its presence...
7.
Ferns G, Raines E, Sprugel K, Motani A, Reidy M, Ross R
Science
. 1991 Sep;
253(5024):1129-32.
PMID: 1653454
Approximately 30 to 40 percent of atherosclerotic coronary arteries treated by angioplasty or by bypass surgery occlude as a result of restenosis. This restenosis is due principally to the accumulation...
8.
Sprugel K, Greenhalgh D, Murray M, Ross R
Prog Clin Biol Res
. 1991 Jan;
365:327-40.
PMID: 1862143
No abstract available.
9.
Greenhalgh D, Sprugel K, Murray M, Ross R
Am J Pathol
. 1990 Jun;
136(6):1235-46.
PMID: 2356856
To examine the effects of recombinant growth factors in vivo, impaired wound healing was studied in genetically diabetic C57BL/KsJ-db/db mice. Large full-thickness skin wounds made on the backs of these...
10.
Ferns G, Sprugel K, Seifert R, Bowen-Pope D, Kelly J, Murray M, et al.
Growth Factors
. 1990 Jan;
3(4):315-24.
PMID: 2175209
Platelet-derived growth factor (PDGF) receptor transfectants of a fibroblastoid cell line (BHK) have been used to investigate the ability of the three dimeric forms of PDGF to elicit a chemotactic...