K Craig Kent
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Explore the profile of K Craig Kent including associated specialties, affiliations and a list of published articles.
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226
Citations
4543
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Recent Articles
1.
Shirasu T, Yodsanit N, Li J, Huang Y, Xie X, Tang R, et al.
Biomaterials
. 2023 Jul;
301:122245.
PMID: 37467597
Open vascular reconstructions such as bypass are common treatments for cardiovascular disease. Unfortunately, neointimal hyperplasia (IH) follows, leading to treatment failure for which there is no approved therapy. Here we...
2.
Dimick J, Harris C, Barrett M, Kent K, Sosa J, Farmer D
Ann Surg
. 2023 Jul;
278(4):471-478.
PMID: 37436884
No abstract available.
3.
Zhang M, Li J, Wang Q, Urabe G, Tang R, Huang Y, et al.
Mol Ther Nucleic Acids
. 2023 Mar;
31:717-729.
PMID: 36923952
Epigenetically switched, proliferative vascular smooth muscle cells (SMCs) form neointima, engendering stenotic diseases. Histone-3 lysine-27 trimethylation (H3K27me3) and acetylation (H3K27ac) marks are associated with gene repression and activation, respectively. The...
4.
Yodsanit N, Shirasu T, Huang Y, Yin L, Islam Z, Gregg A, et al.
Bioact Mater
. 2023 Mar;
26:52-63.
PMID: 36875050
Abdominal aortic aneurysm (AAA) is a progressive aortic dilatation, causing ∼80% mortality upon rupture. Currently, there is no approved drug therapy for AAA. Surgical repairs are invasive and risky and...
5.
Xie X, Shirasu T, Li J, Guo L, Kent K
Cell Death Discov
. 2023 Feb;
9(1):73.
PMID: 36813774
Neointimal hyperplasia (IH) is a common vascular pathology that typically manifests in in-stent restenosis and bypass vein graft failure. Smooth muscle cell (SMC) phenotypic switching is central to IH, both...
6.
Shirasu T, Takagi H, Yasuhara J, Kuno T, Kent K, Farivar B, et al.
Ann Surg
. 2023 Feb;
278(2):172-178.
PMID: 36728522
Objective: The aim was to analyze the risk of progression to chronic limb-threatening ischemia (CLTI), amputation and subsequent interventions after revascularization versus noninvasive therapy in patients with intermittent claudication (IC)....
7.
Shirasu T, Takagi H, Gregg A, Kuno T, Yasuhara J, Kent K, et al.
Eur J Vasc Endovasc Surg
. 2022 Apr;
64(1):32-40.
PMID: 35472449
Objective: The newly proposed Global Limb Anatomic Staging System (GLASS), a categorical staging of infrainguinal artery disease complexity, is expected to correlate with clinical outcomes in patients with chronic limb...
8.
Xie X, Shirasu T, Guo L, Kent K
Atheroscler Plus
. 2022 Apr;
44:31-42.
PMID: 35445204
Background: Vascular smooth muscle cell (SMC) apoptosis is involved in major cardiovascular diseases. Smad2 is a transcription factor implicated in aortic aneurysm. The molecular mediators of Smad2-driven SMC apoptosis are...
9.
Zhang M, Urabe G, Ozer H, Xie X, Webb A, Shirasu T, et al.
Life Sci Alliance
. 2022 Feb;
5(5).
PMID: 35169042
Neointimal hyperplasia/proliferation (IH) is the primary etiology of vascular stenosis. Epigenomic studies concerning IH have been largely confined to in vitro models, and IH-underlying epigenetic mechanisms remain poorly understood. This...
10.
Shirasu T, Takagi H, Yasuhara J, Kuno T, Kent K, Clouse W
Vasc Med
. 2021 Dec;
27(3):261-268.
PMID: 34930052
Pharmacotherapy for undersized abdominal aortic aneurysm (AAA) is a clinical unmet need. Randomized controlled trials (RCTs) have failed to show effectiveness despite countless promising data in preclinical studies. We aimed...