K Craig Kent
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Explore the profile of K Craig Kent including associated specialties, affiliations and a list of published articles.
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226
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4543
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Recent Articles
11.
Shirasu T, Kuno T, Yasuhara J, Yokoyama Y, Takagi H, Cullen M, et al.
J Vasc Surg
. 2021 Sep;
75(1):348-355.e10.
PMID: 34500028
Objective: Controversy has continued regarding the use of endovascular aneurysm repair (EVAR) vs open aneurysm repair (OAR) for infected abdominal aortic aneurysms (AAAs). In the present study, we investigated the...
12.
Zhao Y, Shirasu T, Yodsanit N, Kent E, Ye M, Wang Y, et al.
J Control Release
. 2021 Aug;
338:295-306.
PMID: 34416322
The long-term success of endovascular intervention has long been overshadowed by vessel re-occlusion, also known as restenosis. Mainstream anti-restenotic devices, such as drug-eluting stent (DES) and drug-coated balloon (DCB), were...
13.
Shirasu T, Yodsanit N, Xie X, Zhao Y, Wang Y, Xie R, et al.
Biomaterials
. 2021 Jun;
275:120968.
PMID: 34153787
A major medical problem is the persistent lack of approved therapeutic methods to prevent postoperative intimal hyperplasia (IH) which leads to high-rate failure of open vascular reconstructions such as bypass...
14.
Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, et al.
JACC Basic Transl Sci
. 2021 Mar;
6(3):257-283.
PMID: 33778212
Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF's nuclear activity and...
15.
Wang Q, Ozer H, Wang B, Zhang M, Urabe G, Huang Y, et al.
Mol Ther Methods Clin Dev
. 2021 Mar;
21:54-66.
PMID: 33768129
Bromodomain protein BRD4 reads histone acetylation (H3K27ac), an epigenomic mark of transcription enhancers. CCAAT enhancer binding protein delta (CEBPD) is a transcription factor typically studied in metabolism. While both are...
16.
Zhao Y, Xie R, Yodsanit N, Ye M, Wang Y, Wang B, et al.
Biomater Sci
. 2021 Feb;
9(7):2696-2708.
PMID: 33615323
Occlusion of blood vessels caused by thrombi is the major pathogenesis of various catastrophic cardiovascular diseases. Thrombi can be prevented or treated by antithrombotic drugs. However, free antithrombotic drugs often...
17.
Shen H, Li J, Xie X, Yang H, Zhang M, Wang B, et al.
Life Sci Alliance
. 2020 Nov;
4(1).
PMID: 33234676
The sigma-2 receptor (S2R) has long been pharmacologically targeted for antipsychotic treatment and tumor imaging. Only recently was it known for its coding gene and for its role implicated in...
18.
Yodsanit N, Wang B, Zhao Y, Guo L, Kent K, Gong S
Biomaterials
. 2020 Sep;
265:120406.
PMID: 32979792
An abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta that plagues millions. Its rupture incurs high mortality rates (~80-90%), pressing an urgent need for therapeutic methods to...
19.
PERK Inhibition Promotes Post-angioplasty Re-endothelialization via Modulating SMC Phenotype Changes
Wang B, Zhang M, Urabe G, Shirasu T, Guo L, Kent K
J Surg Res
. 2020 Sep;
257:294-305.
PMID: 32871430
Background: Drug-eluting stents impair post-angioplasty re-endothelialization thus compromising restenosis prevention while heightening thrombotic risks. We recently found that inhibition of protein kinase RNA-like endoplasmic reticulum kinase (PERK) effectively mitigated both...
20.
Huang Y, Urabe G, Zhang M, Li J, Ozer H, Wang B, et al.
Atherosclerosis
. 2020 Aug;
308:22-31.
PMID: 32799103
Background And Aims: Histone methyltransferases are emerging targets for epigenetic therapy. DOT1L (disruptor of telomeric silencing 1-like) is the only known methylation writer at histone 3 lysine 79 (H3K79). It...