Justin W C Leung
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Explore the profile of Justin W C Leung including associated specialties, affiliations and a list of published articles.
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20
Citations
311
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Recent Articles
1.
Lee S, Kelliher J, Song W, Tengler K, Sarkar A, Dray E, et al.
J Biol Chem
. 2023 Jul;
299(8):105043.
PMID: 37451480
The ubiquitin signaling pathway is crucial for the DNA damage response pathway. More specifically, RNF168 is integral in regulating DNA repair proteins at damaged chromatin. However, the detailed mechanism by...
2.
Goines S, Deng M, Glasscott M, Leung J, Dick J
Analyst
. 2022 Jun;
147(15):3612.
PMID: 35766311
Correction for 'Enhancing scanning electrochemical microscopy's potential to probe dynamic co-culture systems hyperspectral assisted-imaging' by Sondrica Goines , , 2022, , 2396-2404, https://doi.org/10.1039/D2AN00319H.
3.
Goines S, Deng M, Glasscott M, Leung J, Dick J
Analyst
. 2022 May;
147(11):2396-2404.
PMID: 35579029
Precise determination of boundaries in co-culture systems is difficult to achieve with scanning electrochemical microscopy alone. Thus, biological scanning electrochemical microscope platforms generally consist of a scanning electrochemical microscope positioner...
4.
Lee D, Apelt K, Lee S, Chan H, Luijsterburg M, Leung J, et al.
Nucleic Acids Res
. 2022 Mar;
50(7):3922-3943.
PMID: 35253893
An inability to repair DNA double-strand breaks (DSBs) threatens genome integrity and can contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly through homologous recombination (HR) and nonhomologous...
5.
Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman J, et al.
Nucleic Acids Res
. 2021 Feb;
49(4):2065-2084.
PMID: 33555350
We previously reported that human Rev1 (hRev1) bound to a parallel-stranded G-quadruplex (G4) from the c-MYC promoter with high affinity. We have extended those results to include other G4 motifs,...
6.
Dong C, West K, Tan X, Li J, Ishibashi T, Yu C, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(29):17019-17030.
PMID: 32611815
DNA double-strand breaks (DSBs) trigger transient pausing of nearby transcription, an emerging ATM-dependent response that suppresses chromosomal instability. We screened a chemical library designed to target the human kinome for...
7.
Kelliher J, West K, Gong Q, Leung J
Nat Commun
. 2020 May;
11(1):2462.
PMID: 32424115
Histone ubiquitination plays an important role in the DNA damage response (DDR) pathway. RNF168 catalyzes H2A and H2AX ubiquitination on lysine 13/15 (K13/K15) upon DNA damage and promotes the accrual...
8.
Sadhukhan R, Leung J, Garg S, Krager K, Savenka A, Basnakian A, et al.
Sci Rep
. 2020 May;
10(1):7734.
PMID: 32382091
Kruppel-like factor 2 (KLF2) is a positive transcriptional regulator of several endothelial protective molecules, including thrombomodulin (TM), a surface receptor, and endothelial nitric oxide synthase (eNOS), an enzyme that generates...
9.
West K, Kelliher J, Xu Z, An L, Reed M, Eoff R, et al.
Nucleic Acids Res
. 2019 Apr;
47(12):6236-6249.
PMID: 30982887
The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged chromatin. Current evidence indicates that 53BP1...
10.
Leung J, Emery L, Miller K
Methods Mol Biol
. 2018 Aug;
1832:255-269.
PMID: 30073532
Histone H2A variants play important roles in maintaining the integrity of the genome. For example, the histone variant H2AX is phosphorylated on Ser139 (called γH2AX) at DNA double-strand breaks (DSB)...