Justin R Prigge
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Explore the profile of Justin R Prigge including associated specialties, affiliations and a list of published articles.
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24
Citations
1035
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Recent Articles
1.
DeBlasi J, Falzone A, Caldwell S, Prieto-Farigua N, Prigge J, Schmidt E, et al.
Cancer Res
. 2023 Apr;
83(12):1953-1967.
PMID: 37062029
Significance: Stabilization of the transcription factor NRF2 promotes oncogene-driven tumor initiation but blocks tumor progression, indicating distinct, threshold-dependent effects of the KEAP1/NRF2 pathway in different stages of lung tumorigenesis.
2.
Miller C, Kundert J, Prigge J, Amato J, Perez A, Coppo L, et al.
Antioxidants (Basel)
. 2021 Mar;
10(3).
PMID: 33673577
Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine catabolism sustains...
3.
McLoughlin M, Orlicky D, Prigge J, Krishna P, Talago E, Cavigli I, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(23):11408-11417.
PMID: 31097586
Thioredoxin reductase-1 (TrxR1)-, glutathione reductase (Gsr)-, and Nrf2 transcription factor-driven antioxidant systems form an integrated network that combats potentially carcinogenic oxidative damage yet also protects cancer cells from oxidative death....
4.
Romero R, Sayin V, Davidson S, Bauer M, Singh S, LeBoeuf S, et al.
Nat Med
. 2017 Oct;
23(11):1362-1368.
PMID: 28967920
Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One approach to addressing this challenge is to...
5.
Fan H, Paiboonrungruan C, Zhang X, Prigge J, Schmidt E, Sun Z, et al.
Biochem Biophys Res Commun
. 2017 Aug;
493(1):833-839.
PMID: 28821430
Oxidative stress is known to play a pivotal role in the development of oral squamous cell carcinoma (OSCC). We have demonstrated that activation of the nuclear factor erythroid 2-related factor...
6.
Prigge J, Coppo L, Martin S, Ogata F, Miller C, Bruschwein M, et al.
Cell Rep
. 2017 Jun;
19(13):2771-2781.
PMID: 28658624
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant...
7.
Lan A, Li W, Liu Y, Xiong Z, Zhang X, Zhou S, et al.
Oncotarget
. 2016 Jul;
7(33):53502-53514.
PMID: 27447968
Oxidative stress is known to play an important role in oral cancer development. In this study we aimed to examine whether a chemical activator of NRF2, sulforaphane (SFN), may have...
8.
Shepardson K, Larson K, Morton R, Prigge J, Schmidt E, Huber V, et al.
mBio
. 2016 May;
7(3).
PMID: 27143388
Unlabelled: Bacterial superinfections are a primary cause of death during influenza pandemics and epidemics. Type I interferon (IFN) signaling contributes to increased susceptibility of mice to bacterial superinfection around day...
9.
Doka E, Pader I, Biro A, Johansson K, Cheng Q, Ballago K, et al.
Sci Adv
. 2016 Feb;
2(1):e1500968.
PMID: 26844296
Hydrogen sulfide signaling involves persulfide formation at specific protein Cys residues. However, overcoming current methodological challenges in persulfide detection and elucidation of Cys regeneration mechanisms from persulfides are prerequisites for...
10.
Prigge J, Hoyt T, Dobrinen E, Capecchi M, Schmidt E, Meissner N
J Immunol
. 2015 Nov;
195(11):5347-57.
PMID: 26519535
Although acquired bone marrow failure (BMF) is considered a T cell-mediated autoimmune disease, few studies have considered contributing roles of innate immune deviations following otherwise innocuous infections as a cause...