Justin Kern
Overview
Explore the profile of Justin Kern including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
162
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Recent Articles
1.
Hammoud S, Kern J, Mukherjee S, Lutkewitte A, Singh P, Newberry K, et al.
Am J Physiol Renal Physiol
. 2025 Jan;
PMID: 39819047
The kidney is highly metabolically active, and injury induces changes in metabolism that can impact repair and fibrosis progression. Changes in expression of metabolism-related genes and proteins provide valuable data,...
2.
Sun S, Hodel M, Wang X, De Vicente J, Haritunians T, Debebe A, et al.
Sci Immunol
. 2024 Nov;
9(101):eadi7907.
PMID: 39514635
polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson's disease and Crohn's disease (CD) lead to LRRK2 kinase hyperactivity and suppress autophagy. This connection suggests that LRRK2 kinase inhibition, a therapeutic strategy...
3.
Hung C, Ma C, Panda S, Trsan T, Hodel M, Frein J, et al.
Mucosal Immunol
. 2024 Jul;
17(5):1019-1028.
PMID: 38992433
The prevalence of obesity in the United States has continued to increase over the past several decades. Understanding how diet-induced obesity modulates mucosal immunity is of clinical relevance. We previously...
4.
Hammoud S, Ivanova A, Osaki Y, Funk S, Yang H, Viquez O, et al.
JCI Insight
. 2024 May;
9(9).
PMID: 38716735
No abstract available.
5.
Hammoud S, Ivanova A, Osaki Y, Funk S, Yang H, Viquez O, et al.
JCI Insight
. 2024 Mar;
9(6).
PMID: 38516886
Kidney tubules use fatty acid oxidation (FAO) to support their high energetic requirements. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO, and it is necessary to transport long-chain...
6.
Malique A, Sun S, Chandwe K, Amadi B, Haritunians T, Jain U, et al.
Sci Transl Med
. 2024 Jan;
16(728):eabq4145.
PMID: 38170788
Environmental enteric dysfunction (EED) is a diffuse small bowel disorder associated with poor growth, inadequate responses to oral vaccines, and nutrient malabsorption in millions of children worldwide. We identify loss...
7.
Osaki Y, Manolopoulou M, Ivanova A, Vartanian N, Phillips Mignemi M, Kern J, et al.
JCI Insight
. 2022 Jun;
7(12).
PMID: 35730565
Acute and chronic kidney injuries induce increased cell cycle progression in renal tubules. While increased cell cycle progression promotes repair after acute injury, the role of ongoing tubular cell cycle...
8.
Kern J, Wilton R, Zhang R, Binkowski T, Joachimiak A, Schneewind O
J Biol Chem
. 2011 May;
286(29):26042-9.
PMID: 21572039
Surface (S)-layers, para-crystalline arrays of protein, are deposited in the envelope of most bacterial species. These surface organelles are retained in the bacterial envelope through the non-covalent association of proteins...
9.
Kern J, Ryan C, Faull K, Schneewind O
J Mol Biol
. 2010 Jul;
401(5):757-75.
PMID: 20603129
Bacillus anthracis, the causative agent of anthrax, requires surface (S)-layer proteins for the pathogenesis of infection. Previous work characterized S-layer protein binding via the surface layer homology domain to a...
10.
Kern J, Schneewind O
Mol Microbiol
. 2009 Nov;
75(2):324-32.
PMID: 19906175
Microbial pathogens use adhesive surface proteins to bind to and interact with host tissues, events that are universal for the pathogenesis of infectious diseases. A surface adhesin of Bacillus anthracis,...