Justin Decarreau
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Explore the profile of Justin Decarreau including associated specialties, affiliations and a list of published articles.
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22
Citations
236
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Recent Articles
1.
Vazquez Torres S, Benard Valle M, Mackessy S, Menzies S, Casewell N, Ahmadi S, et al.
Nature
. 2025 Jan;
639(8053):225-231.
PMID: 39814879
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic...
2.
Rankovic S, Carr K, Decarreau J, Skotheim R, Kibler R, Ols S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484564
Recent advances in computational methods have led to considerable progress in the design of self-assembling protein nanoparticles. However, nearly all nanoparticles designed to date exhibit strict point group symmetry, with...
3.
Liu C, Wu K, Choi H, Han H, Zhang X, Watson J, et al.
bioRxiv
. 2024 Jul;
PMID: 39071267
Proteins which bind intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could have considerable utility for therapeutic and diagnostic applications. However, a general methodology...
4.
Vazquez Torres S, Benard Valle M, Mackessy S, Menzies S, Casewell N, Ahmadi S, et al.
Res Sq
. 2024 May;
PMID: 38798548
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more. Three-finger toxins (3FTx) are highly toxic...
5.
Yang E, Divine R, Miranda M, Borst A, Sheffler W, Zhang J, et al.
Nat Struct Mol Biol
. 2024 May;
31(9):1404-1412.
PMID: 38724718
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for targeted delivery of biologics. Here we describe the design...
6.
Vicente J, Wagenbach M, Decarreau J, Zelter A, MacCoss M, Davis T, et al.
bioRxiv
. 2024 Apr;
PMID: 38617353
Centrosomes are the principal microtubule-organizing centers of the cell and play an essential role in mitotic spindle function. Centrosome biogenesis is achieved by strict control of protein acquisition and phosphorylation...
7.
Shen H, Lynch E, Akkineni S, Watson J, Decarreau J, Bethel N, et al.
Nat Nanotechnol
. 2024 Apr;
19(7):1016-1021.
PMID: 38570702
Biological evolution has led to precise and dynamic nanostructures that reconfigure in response to pH and other environmental conditions. However, designing micrometre-scale protein nanostructures that are environmentally responsive remains a...
8.
Sahtoe D, Andrzejewska E, Han H, Rennella E, Schneider M, Meisl G, et al.
Nat Chem Biol
. 2024 Mar;
20(8):981-990.
PMID: 38503834
Segments of proteins with high β-strand propensity can self-associate to form amyloid fibrils implicated in many diseases. We describe a general approach to bind such segments in β-strand and β-hairpin...
9.
Mout R, Bretherton R, Decarreau J, Lee S, Gregorio N, Edman N, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(6):e2309457121.
PMID: 38289949
Relating the macroscopic properties of protein-based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit computational design to specify the size, flexibility, and valency of de...
10.
Olshefsky A, Benasutti H, Sylvestre M, Butterfield G, Rocklin G, Richardson C, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(46):e2306129120.
PMID: 37939083
Controlling the biodistribution of protein- and nanoparticle-based therapeutic formulations remains challenging. In vivo library selection is an effective method for identifying constructs that exhibit desired distribution behavior; library variants can...