Danny D Sahtoe
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Explore the profile of Danny D Sahtoe including associated specialties, affiliations and a list of published articles.
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14
Citations
443
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Recent Articles
1.
Broerman A, Pollmann C, Lichtenstein M, Jackson M, Tessmer M, Ryu W, et al.
bioRxiv
. 2024 Nov;
PMID: 39605600
Protein design has focused primarily on the design of ground states, ensuring they are sufficiently low energy to be highly populated. Designing the kinetics and dynamics of a system requires,...
2.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, et al.
Nature
. 2024 Sep;
638(8051):796-804.
PMID: 39322662
Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by endogenous ligands. Therapeutic approaches such as lysosome-targeting chimaeras (LYTACs) and cytokine receptor-targeting chimeras (KineTACs) have used this to...
3.
Sahtoe D, Andrzejewska E, Han H, Rennella E, Schneider M, Meisl G, et al.
Nat Chem Biol
. 2024 Mar;
20(8):981-990.
PMID: 38503834
Segments of proteins with high β-strand propensity can self-associate to form amyloid fibrils implicated in many diseases. We describe a general approach to bind such segments in β-strand and β-hairpin...
4.
Mout R, Bretherton R, Decarreau J, Lee S, Gregorio N, Edman N, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(6):e2309457121.
PMID: 38289949
Relating the macroscopic properties of protein-based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit computational design to specify the size, flexibility, and valency of de...
5.
Mout R, Bretherton R, Decarreau J, Lee S, Edman N, Ahlrichs M, et al.
bioRxiv
. 2023 Jul;
PMID: 37398067
Relating the macroscopic properties of protein-based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit computational design to specify the size, flexibility, and valency of protein...
6.
Rennella E, Sahtoe D, Baker D, Kay L
Proc Natl Acad Sci U S A
. 2023 Apr;
120(18):e2303149120.
PMID: 37094170
With the recent success in calculating protein structures from amino acid sequences using artificial intelligence-based algorithms, an important next step is to decipher how dynamics is encoded by the primary...
7.
Sahtoe D, Praetorius F, Courbet A, Hsia Y, Wicky B, Edman N, et al.
Science
. 2022 Jan;
375(6578):eabj7662.
PMID: 35050655
Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces that enable reversible association...
8.
Vulovic I, Yao Q, Park Y, Courbet A, Norris A, Busch F, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34074752
Protein nanomaterial design is an emerging discipline with applications in medicine and beyond. A long-standing design approach uses genetic fusion to join protein homo-oligomer subunits via α-helical linkers to form...
9.
Sahtoe D, Coscia A, Mustafaoglu N, Miller L, Olal D, Vulovic I, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33879614
The de novo design of polar protein-protein interactions is challenging because of the thermodynamic cost of stripping water away from the polar groups. Here, we describe a general approach for...
10.
Sahtoe D, van Dijk W, Ekkebus R, Ovaa H, Sixma T
Nat Commun
. 2016 Jan;
7:10292.
PMID: 26739236
The deubiquitinating enzyme BAP1 is an important tumor suppressor that has drawn attention in the clinic since its loss leads to a variety of cancers. BAP1 is activated by ASXL1...