Justin Crocker
Overview
Explore the profile of Justin Crocker including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
751
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Recent Articles
1.
Perkins M, Crocker J, Tkacik G
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2411887121.
PMID: 39793086
Biophysical constraints limit the specificity with which transcription factors (TFs) can target regulatory DNA. While individual nontarget binding events may be low affinity, the sheer number of such interactions could...
2.
Gandara L, Foreman A, Crocker J
Curr Opin Insect Sci
. 2024 Dec;
68:101324.
PMID: 39731925
Insect populations are declining globally, with multiple potential drivers identified. However, experimental data are needed to understand their relative contributions. We highlight the sublethal effects of pesticides at field-relevant concentrations,...
3.
Gandara L, Jacoby R, Laurent F, Spatuzzi M, Vlachopoulos N, Borst N, et al.
Science
. 2024 Oct;
386(6720):446-453.
PMID: 39446951
Insect biomass is declining globally, likely driven by climate change and pesticide use, yet systematic studies on the effects of various chemicals remain limited. In this work, we used a...
4.
Li X, Srinivasan V, Laiker I, Misunou N, Frankel N, Pallares L, et al.
Mol Biol Evol
. 2024 Aug;
41(8).
PMID: 39117360
Understanding the evolutionary potential of mutations in gene regulatory networks is essential to furthering the study of evolution and development. However, in multicellular systems, genetic manipulation of regulatory networks in...
5.
Laurent F, Blanc A, May L, Gandara L, Cocanougher B, Jones B, et al.
Bioinformatics
. 2024 Jul;
40(7).
PMID: 38970365
Motivation: As more behavioural assays are carried out in large-scale experiments on Drosophila larvae, the definitions of the archetypal actions of a larva are regularly refined. In addition, video recording...
6.
Li X, Gandara L, Ekelof M, Richter K, Alexandrov T, Crocker J
Nat Commun
. 2024 May;
15(1):4551.
PMID: 38811562
Although the effects of genetic and environmental perturbations on multicellular organisms are rarely restricted to single phenotypic layers, our current understanding of how developmental programs react to these challenges remains...
7.
Nora E, Aerts S, Wittkopp P, Bussemaker H, Bulyk M, Sinha S, et al.
Cell Syst
. 2023 Apr;
14(4):247-251.
PMID: 37080160
What new questions can we ask about transcriptional regulation given recent developments in large-scale approaches?
8.
Li X, Fuqua T, van Breugel M, Crocker J
Philos Trans R Soc Lond B Biol Sci
. 2023 Apr;
378(1877):20220054.
PMID: 37004721
Rapid enhancer and slow promoter evolution have been demonstrated through comparative genomics. However, it is not clear how this information is encoded genetically and if this can be used to...
9.
Crocker J, Payne J, Walczak A, Wittkopp P
Philos Trans R Soc Lond B Biol Sci
. 2023 Apr;
378(1877):20220042.
PMID: 37004718
No abstract available.
10.
Galupa R, Alvarez-Canales G, Borst N, Fuqua T, Gandara L, Misunou N, et al.
Dev Cell
. 2023 Jan;
58(1):51-62.e4.
PMID: 36626871
Developmental enhancers bind transcription factors and dictate patterns of gene expression during development. Their molecular evolution can underlie phenotypical evolution, but the contributions of the evolutionary pathways involved remain little...