Justin A North
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Explore the profile of Justin A North including associated specialties, affiliations and a list of published articles.
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27
Citations
911
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Recent Articles
1.
Crowther T, Rappuoli R, Corinaldesi C, Danovaro R, Donohue T, Huisman J, et al.
Cell
. 2024 Sep;
187(19):5195-5216.
PMID: 39303686
Microorganisms, including bacteria, archaea, viruses, fungi, and protists, are essential to life on Earth and the functioning of the biosphere. Here, we discuss the key roles of microorganisms in achieving...
2.
Huening K, Groves J, Wildenthal J, Tabita F, North J
Microbiol Spectr
. 2024 Mar;
12(4):e0308623.
PMID: 38441472
Importance: The acquisition and utilization of organic compounds that serve as growth substrates are essential for to grow and multiply. Ubiquitous enzymatic reactions involving S-adenosyl-l-methionine as a co-substrate by all...
3.
Huening K, Groves J, Wildenthal J, Tabita F, North J
bioRxiv
. 2023 Aug;
PMID: 37609188
All organisms utilize -adenosyl-l-methionine (SAM) as a key co-substrate for methylation of biological molecules, synthesis of polyamines, and radical SAM reactions. When these processes occur, 5'-deoxy-nucleosides are formed as byproducts...
4.
North J, Narrowe A, Xiong W, Byerly K, Zhao G, Young S, et al.
Science
. 2020 Aug;
369(6507):1094-1098.
PMID: 32855335
Bacterial production of gaseous hydrocarbons such as ethylene and methane affects soil environments and atmospheric climate. We demonstrate that biogenic methane and ethylene from terrestrial and freshwater bacteria are directly...
5.
North J, Wildenthal J, Erb T, Evans B, Byerly K, Gerlt J, et al.
Mol Microbiol
. 2020 Jan;
113(5):923-937.
PMID: 31950558
S-adenosyl-l-methionine (SAM) is a necessary cosubstrate for numerous essential enzymatic reactions including protein and nucleotide methylations, secondary metabolite synthesis and radical-mediated processes. Radical SAM enzymes produce 5'-deoxyadenosine, and SAM-dependent enzymes...
6.
Satagopan S, North J, Arbing M, Varaljay V, Haines S, Wildenthal J, et al.
Biochemistry
. 2019 Aug;
58(37):3880-3892.
PMID: 31456394
The enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its central role in capturing atmospheric CO via the Calvin-Benson-Bassham (CBB) cycle have been well-studied. Previously, a form II RuBisCO from , a...
7.
Miller A, North J, Wildenthal J, Tabita F
mBio
. 2018 Apr;
9(2).
PMID: 29636438
5'-Methyl-thioadenosine (MTA) is a dead-end, sulfur-containing metabolite and cellular inhibitor that arises from adenosyl-l-methionine-dependent reactions. Recent studies have indicated that there are diverse bacterial ethionine alvage athways (MSPs) for MTA...
8.
North J, Miller A, Wildenthal J, Young S, Tabita F
Proc Natl Acad Sci U S A
. 2017 Nov;
114(48):E10455-E10464.
PMID: 29133429
Numerous cellular processes involving -adenosyl-l-methionine result in the formation of the toxic by-product, 5'-methylthioadenosine (MTA). To prevent inhibitory MTA accumulation and retain biologically available sulfur, most organisms possess the "universal"...
9.
North J, Sriram J, Chourey K, Ecker C, Sharma R, Wildenthal J, et al.
mBio
. 2016 Jul;
7(4).
PMID: 27406564
Unlabelled: Rhodospirillum rubrum possesses a novel oxygen-independent, aerobic methionine salvage pathway (MSP) for recycling methionine from 5-methylthioadenosine (MTA), the MTA-isoprenoid shunt. This organism can also metabolize MTA as a sulfur...
10.
Teeling-Smith R, Jung Y, Scozzaro N, Cardellino J, Rampersaud I, North J, et al.
Biophys J
. 2016 May;
110(9):2044-52.
PMID: 27166812
Electron paramagnetic resonance (EPR), an established and powerful methodology for studying atomic-scale biomolecular structure and dynamics, typically requires in excess of 10(12) labeled biomolecules. Single-molecule measurements provide improved insights into...