Junichiro Tohyama
Overview
Explore the profile of Junichiro Tohyama including associated specialties, affiliations and a list of published articles.
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11
Citations
316
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Recent Articles
1.
Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, et al.
Science
. 2021 Jul;
373(6554).
PMID: 34326208
Emerging studies indicate that the immune system can regulate systemic metabolism. Here, we show that thymic stromal lymphopoietin (TSLP) stimulates T cells to induce selective white adipose loss, which protects...
2.
Zhang H, Shi J, Hachet M, Xue C, Bauer R, Jiang H, et al.
Arterioscler Thromb Vasc Biol
. 2017 Sep;
37(11):2156-2160.
PMID: 28882870
Objective: To gain mechanistic insights into the role of (lipase A), the gene encoding LAL (lysosomal acid lipase) protein, in human macrophages. Approach And Results: We used CRISPR (clustered regularly...
3.
Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor W, Szapary H, et al.
J Lipid Res
. 2017 Feb;
58(4):731-741.
PMID: 28137768
Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed...
4.
Millar J, Reyes-Soffer G, Jumes P, Dunbar R, deGoma E, Baer A, et al.
J Clin Invest
. 2016 Apr;
126(4):1603-4.
PMID: 27035815
No abstract available.
5.
Millar J, Reyes-Soffer G, Jumes P, Dunbar R, deGoma E, Baer A, et al.
J Clin Invest
. 2015 May;
125(6):2510-22.
PMID: 25961461
Background: Individuals treated with the cholesteryl ester transfer protein (CETP) inhibitor anacetrapib exhibit a reduction in both LDL cholesterol and apolipoprotein B (ApoB) in response to monotherapy or combination therapy...
6.
Bauer R, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, et al.
Circulation
. 2015 Feb;
131(13):1202-1213.
PMID: 25712206
Background: Genome-wide association studies have established ADAMTS7 as a locus for coronary artery disease in humans. However, these studies fail to provide directionality for the association between ADAMTS7 and coronary...
7.
Patel K, Strong A, Tohyama J, Jin X, Morales C, Billheimer J, et al.
Circ Res
. 2015 Jan;
116(5):789-96.
PMID: 25593281
Rationale: Noncoding gene variants at the SORT1 locus are strongly associated with low-density lipoprotein cholesterol (LDL-C) levels, as well as with coronary artery disease. SORT1 encodes a protein called sortilin,...
8.
Jin S, Tohyama J, Bauer R, Cao N, Rader D, Zheng X
Arterioscler Thromb Vasc Biol
. 2012 Jun;
32(8):1817-23.
PMID: 22652598
Objective: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats-13) cleaves von Willebrand factor, thereby modulating thrombosis and inflammation. Low plasma ADAMTS13 activity is associated with cardiovascular events, including...
9.
Nakaya K, Tohyama J, Naik S, Tanigawa H, Macphee C, Billheimer J, et al.
Arterioscler Thromb Vasc Biol
. 2011 Mar;
31(6):1276-82.
PMID: 21441141
Objective: Peroxisome proliferator-activated receptor-α (PPARα) activation has been shown in vitro to increase macrophage cholesterol efflux, the initial step in reverse cholesterol transport (RCT). However, it remains unclear whether PPARα...
10.
Tohyama J, Billheimer J, Fuki I, Rothblat G, Rader D, Millar J
Atherosclerosis
. 2008 Nov;
204(2):418-23.
PMID: 18990393
Objective: The mechanism by which non-nucleoside reverse transcriptase inhibitors (NNRTIs) increase HDL cholesterol (HDL-C) in HIV+ patients and the benefits of this with respect to cardiovascular risk are not known....