Junhui Duan
Overview
Explore the profile of Junhui Duan including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
791
Followers
0
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Recent Articles
1.
Ma R, Salinas N, Orr-Gonzalez S, Richardson B, Ouahes T, Torano H, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1011879.
PMID: 38437239
Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the accumulation of infected erythrocytes in the placenta...
2.
Sagara I, Healy S, Assadou M, Kone M, Swihart B, Kwan J, et al.
Lancet Infect Dis
. 2023 Jul;
23(11):1266-1279.
PMID: 37499679
Background: Malaria transmission-blocking vaccines target mosquito-stage parasites and will support elimination programmes. Gamete vaccine Pfs230D1-EPA/Alhydrogel induced superior activity to zygote vaccine Pfs25-EPA/Alhydrogel in malaria-naive US adults. Here, we compared these...
3.
Mwakingwe-Omari A, Healy S, Lane J, Cook D, Kalhori S, Wyatt C, et al.
Nature
. 2021 Jul;
595(7866):289-294.
PMID: 34194041
The global decline in malaria has stalled, emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination (CVac), for which aseptic, purified, cryopreserved,...
4.
Doritchamou J, Morrison R, Renn J, Ribeiro J, Duan J, Fried M, et al.
Commun Biol
. 2019 Dec;
2:457.
PMID: 31840102
Two vaccines based on protein VAR2CSA are currently in clinical evaluation to prevent placental malaria (PM), but a deeper understanding of variability could impact vaccine design. Here we identified atypical...
5.
Griffin C, Hoke J, Samarakoon U, Duan J, Mu J, Ferdig M, et al.
Antimicrob Agents Chemother
. 2012 Aug;
56(10):5356-64.
PMID: 22869567
The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and in vivo...
6.
Ouattara A, Mu J, Takala-Harrison S, Saye R, Sagara I, Dicko A, et al.
Malar J
. 2010 Jun;
9:175.
PMID: 20565971
Background: Extensive genetic diversity in vaccine antigens may contribute to the lack of efficacy of blood stage malaria vaccines. Apical membrane antigen-1 (AMA1) is a leading blood stage malaria vaccine...
7.
Duan J, Mu J, Thera M, Joy D, Kosakovsky Pond S, Diemert D, et al.
Proc Natl Acad Sci U S A
. 2008 Jun;
105(22):7857-62.
PMID: 18515425
Immunization with the highly polymorphic Plasmodium falciparum apical membrane antigen 1 (PfAMA1) induces protection in animals but primarily against parasites that express the same or similar alleles. One strategy to...
8.
Mu J, Awadalla P, Duan J, McGee K, Keebler J, Seydel K, et al.
Nat Genet
. 2006 Dec;
39(1):126-30.
PMID: 17159981
One goal in sequencing the Plasmodium falciparum genome, the agent of the most lethal form of malaria, is to discover vaccine and drug targets. However, identifying those targets in a...
9.
Furuya T, Mu J, Hayton K, Liu A, Duan J, Nkrumah L, et al.
Proc Natl Acad Sci U S A
. 2005 Nov;
102(46):16813-8.
PMID: 16275909
A male gametocyte defect in the Plasmodium falciparum Dd2 parasite was previously discovered through the observation that all progeny clones in a Dd2 x HB3 genetic cross were the result...
10.
Mu J, Awadalla P, Duan J, McGee K, Joy D, McVean G, et al.
PLoS Biol
. 2005 Sep;
3(10):e335.
PMID: 16144426
Understanding the influences of population structure, selection, and recombination on polymorphism and linkage disequilibrium (LD) is integral to mapping genes contributing to drug resistance or virulence in Plasmodium falciparum. The...