Julio Martin
Overview
Explore the profile of Julio Martin including associated specialties, affiliations and a list of published articles.
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43
Citations
634
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Recent Articles
1.
Tavernelli L, Alonso V, Pena I, Rodriguez Araya E, Manarin R, Cantizani J, et al.
Antimicrob Agents Chemother
. 2024 Jul;
68(8):e0024324.
PMID: 39028190
Bromodomains are structural folds present in all eukaryotic cells that bind to other proteins recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear complexes that interact with acetylated...
2.
Thomas M, McGonagle K, Rowland P, Robinson D, Dodd P, Camino-Diaz I, et al.
J Med Chem
. 2023 Jul;
66(15):10413-10431.
PMID: 37506194
There is an urgent need for new treatments for Chagas disease, a parasitic infection which mostly impacts South and Central America. We previously reported on the discovery of GSK3494245/DDD01305143, a...
3.
Estrada Y, Lozano A, Teran A, Eckembrecher D, Rojas L, Tamayo C, et al.
PLOS Glob Public Health
. 2023 May;
3(5):e0000694.
PMID: 37228000
Interventions that address adolescent conduct problems are essential for decreasing negative risk behaviors and promoting positive protective factors among youth. Although interventions have been developed and tested in the United...
4.
Jones N, Geoghegan V, Moore G, Carnielli J, Newling K, Calderon F, et al.
Nat Commun
. 2022 Jul;
13(1):4071.
PMID: 35831302
Leishmania are unicellular parasites that cause human and animal diseases. Like other kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by histone variants and histone lysine acetylation....
5.
Pezza A, Tavernelli L, Alonso V, Perdomo V, Gabarro R, Prinjha R, et al.
ACS Infect Dis
. 2022 Apr;
8(5):1062-1074.
PMID: 35482332
is a unicellular parasite that causes Chagas disease, which is endemic in the American continent but also worldwide, distributed by migratory movements. A striking feature of trypanosomatids is the polycistronic...
6.
Hefnawy A, Negreira G, Jara M, Cotton J, Maes I, Dhaenens E, et al.
mBio
. 2022 Jan;
13(1):e0326421.
PMID: 35012338
The implementation of prospective drug resistance (DR) studies in the research-and-development (R&D) pipeline is a common practice for many infectious diseases but not for neglected tropical diseases (NTDs). Here, we...
7.
Tallant C, Bamborough P, Chung C, Gamo F, Kirkpatrick R, Larminie C, et al.
ACS Infect Dis
. 2021 Oct;
7(11):2953-2958.
PMID: 34612618
This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class...
8.
Cantizani J, Gamallo P, Cotillo I, Alvarez-Velilla R, Martin J
PLoS Negl Trop Dis
. 2021 Jul;
15(7):e0009602.
PMID: 34270544
Chagas disease (CD) is a human disease caused by Trypanosoma cruzi. Whilst endemic in Latin America, the disease is spread around the world due to migration flows, being estimated that...
9.
Thomas M, Brand S, De Rycker M, Zuccotto F, Lukac I, Dodd P, et al.
J Med Chem
. 2021 Apr;
64(9):5905-5930.
PMID: 33904304
There is an urgent need for new treatments for visceral leishmaniasis (VL), a parasitic infection which impacts heavily large areas of East Africa, Asia, and South America. We previously reported...
10.
Paradela L, Wall R, Carvalho S, Chemi G, Corpas-Lopez V, Moynihan E, et al.
Cell Chem Biol
. 2021 Mar;
28(5):711-721.e8.
PMID: 33691122
Phenotypic screening identified a benzothiophene compound with activity against Leishmania donovani, the causative agent of visceral leishmaniasis. Using multiple orthogonal approaches, oxidosqualene cyclase (OSC), a key enzyme of sterol biosynthesis,...