Expanding Bromodomain Targeting into Neglected Parasitic Diseases

Overview

Journal ACS Infect Dis

Specialties Infectious Diseases
Microbiology
Pharmacology

Date 2021 Oct 6

PMID 34612618

Citations 10

Authors

Cynthia Tallant

Paul Bamborough

Chun-Wa Chung

Francisco Javier Gamo

Robert Kirkpatrick

Chris Larminie

Julio Martin

Rab Prinjha

Inmaculada Rioja

Daniel F Simola

Raquel Gabarro

Felix Calderon

Affiliations

Soon will be listed here.

Abstract

This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launch drug discovery campaigns to identify and develop antiparasite drugs that can offer differentiated mechanisms of action.

Citing Articles

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from (BDF3).

Alonso V, Escalante A, Rodriguez Araya E, Frattini G, Tavernelli L, Moreno D Front Microbiol. 2024; 15:1465672.

PMID: 39411427 PMC: 11473290. DOI: 10.3389/fmicb.2024.1465672.

Small Molecule Ligands of the BET-like Bromodomain, BRD3, Affect Survival, Oviposition, and Development.

Schiedel M, McArdle D, Padalino G, Chan A, Forde-Thomas J, McDonough M J Med Chem. 2023; 66(23):15801-15822.

PMID: 38048437 PMC: 10726355. DOI: 10.1021/acs.jmedchem.3c01321.

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery.

Russell C, Carter J, Borgia J, Bush J, Calderon F, Gabarro R ACS Infect Dis. 2023; 9(11):2340-2357.

PMID: 37906637 PMC: 10644352. DOI: 10.1021/acsinfecdis.3c00431.

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome.

Ashby E, Havens J, Rollosson L, Hardin J, Schulz D Microbiol Spectr. 2023; 11(3):e0014723.

PMID: 37097159 PMC: 10269879. DOI: 10.1128/spectrum.00147-23.

Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum.

Nava M, Calderon F, Fernandez E, Ballell L, Bamborough P, Vinayak S Microbiol Spectr. 2022; 11(1):e0387422.

PMID: 36533912 PMC: 9927415. DOI: 10.1128/spectrum.03874-22.