Julien Peltier
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Explore the profile of Julien Peltier including associated specialties, affiliations and a list of published articles.
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20
Citations
627
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Recent Articles
1.
Simoes de Oliveira L, OLeary H, Nawaz S, Loureiro R, Davenport E, Baxter P, et al.
Mol Autism
. 2024 Jun;
15(1):28.
PMID: 38877552
Background: Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has been...
2.
Bilkei-Gorzo O, Heunis T, Marin-Rubio J, Cianfanelli F, Raymond B, Inns J, et al.
EMBO J
. 2022 Oct;
41(23):e108970.
PMID: 36281581
Phagocytosis is a key process in innate immunity and homeostasis. After particle uptake, newly formed phagosomes mature by acquisition of endolysosomal enzymes. Macrophage activation by interferon gamma (IFN-γ) increases microbicidal...
3.
Govaere O, Petersen S, Martinez-Lopez N, Wouters J, Van Haele M, Mancina R, et al.
J Hepatol
. 2021 Dec;
76(5):1001-1012.
PMID: 34942286
Background & Aims: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely...
4.
Brown H, Williams C, Zhou H, Rios-Szwed D, Fernandez-Alonso R, Mansoor S, et al.
Biochem J
. 2021 Nov;
478(23):4119-4136.
PMID: 34780645
The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not...
5.
Breyer F, Hartlova A, Thurston T, Flynn H, Chakravarty P, Janzen J, et al.
EMBO J
. 2021 Apr;
40(10):e106188.
PMID: 33881780
Tumour progression locus 2 (TPL-2) kinase mediates Toll-like receptor (TLR) activation of ERK1/2 and p38α MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This...
6.
Heap R, Marin-Rubio J, Peltier J, Heunis T, Dannoura A, Moore A, et al.
Life Sci Alliance
. 2021 Apr;
4(6).
PMID: 33853969
BMDMs are a key model system to study macrophage biology in vitro. Commonly used methods to differentiate macrophages from BM are treatment with either recombinant M-CSF or the supernatant of...
7.
Malik N, Nirujogi R, Peltier J, Macartney T, Wightman M, Prescott A, et al.
Biochem J
. 2019 Oct;
476(20):3081-3107.
PMID: 31665227
The serum- and glucocorticoid-regulated kinase (SGK) isoforms contribute resistance to cancer therapies targeting the PI3K pathway. SGKs are homologous to Akt and these kinases display overlapping specificity and phosphorylate several...
8.
Pauwels A, Hartlova A, Peltier J, Driege Y, Baudelet G, Brodin P, et al.
Mol Cell Proteomics
. 2019 Feb;
18(5):909-922.
PMID: 30808727
Dendritic cells (DCs) are professional phagocytes that use innate sensing and phagocytosis to internalize and degrade self as well as foreign material, such as pathogenic bacteria, within phagosomes. These intracellular...
9.
Munoz I, Morgan M, Peltier J, Weiland F, Gregorczyk M, Brown F, et al.
EMBO J
. 2018 Sep;
37(24).
PMID: 30266825
Mutations in the gene encoding the protein kinase CDKL5 cause a debilitating neurodevelopmental disease termed CDKL5 disorder. The impact of these mutations on CDKL5 function is poorly understood because the...
10.
Ostrowski A, Cianfanelli F, Porter M, Mariano G, Peltier J, Wong J, et al.
PLoS Pathog
. 2018 Jul;
14(7):e1007230.
PMID: 30052683
The Type VI secretion system (T6SS) is widely used by bacterial pathogens as an effective weapon against bacterial competitors and is also deployed against host eukaryotic cells in some cases....