Julien Mozziconacci
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Explore the profile of Julien Mozziconacci including associated specialties, affiliations and a list of published articles.
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54
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2145
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Recent Articles
1.
Meneu L, Chapard C, Serizay J, Westbrook A, Routhier E, Ruault M, et al.
Science
. 2025 Feb;
387(6734):eadm9466.
PMID: 39913590
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in...
2.
Das M, Semple J, Haemmerli A, Volodkina V, Scotton J, Gitchev T, et al.
Nat Genet
. 2024 Jul;
56(8):1737-1749.
PMID: 39039278
The structural maintenance of chromosome (SMC) complexes-cohesin and condensins-are crucial for chromosome separation and compaction during cell division. During the interphase, mammalian cohesins additionally fold the genome into loops and...
3.
Routhier E, Joubert A, Westbrook A, Pierre E, Lancrey A, Cariou M, et al.
Nucleic Acids Res
. 2024 Jun;
52(12):6802-6810.
PMID: 38828788
The computational design of synthetic DNA sequences with designer in vivo properties is gaining traction in the field of synthetic genomics. We propose here a computational method which combines a...
4.
Bignaud A, Cockram C, Borde C, Groseille J, Allemand E, Thierry A, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(3):489-497.
PMID: 38177686
Transcription generates local topological and mechanical constraints on the DNA fiber, leading to the generation of supercoiled chromosome domains in bacteria. However, the global impact of transcription on chromosome organization...
5.
Luo J, Vale-Silva L, Raghavan A, Mercy G, Heldrich J, Sun X, et al.
Cell Genom
. 2023 Nov;
3(11):100439.
PMID: 38020967
We designed and synthesized , which is ∼21.6% shorter than native , the smallest chromosome in . was designed for attachment to another synthetic chromosome due to concerns surrounding potential...
6.
Schindler D, Walker R, Jiang S, Brooks A, Wang Y, Muller C, et al.
Cell
. 2023 Nov;
186(24):5237-5253.e22.
PMID: 37944512
Here, we report the design, construction, and characterization of a tRNA neochromosome, a designer chromosome that functions as an additional, de novo counterpart to the native complement of Saccharomyces cerevisiae....
7.
Gil J, Rosin L, Navarrete E, Chowdhury N, Abraham S, Cornilleau G, et al.
bioRxiv
. 2023 Sep;
PMID: 37745315
The hallmarks of chromosome organization in multicellular eukaryotes are chromosome territories (CT), chromatin compartments, and insulated domains, including topologically associated domains (TADs). Yet, most of these elements of chromosome organization...
8.
Lazar-Stefanita L, Luo J, Montagne R, Thierry A, Sun X, Mercy G, et al.
Cell Genom
. 2022 Aug;
2(8):None.
PMID: 35983101
Eukaryotic genomes vary in terms of size, chromosome number, and genetic complexity. Their temporal organization is complex, reflecting coordination between DNA folding and function. Here, we used fused karyotypes of...
9.
Routhier E, Mozziconacci J
PeerJ
. 2022 Jun;
10:e13613.
PMID: 35769139
The tremendous amount of biological sequence data available, combined with the recent methodological breakthrough in deep learning in domains such as computer vision or natural language processing, is leading today...
10.
Lancrey A, Joubert A, Duvernois-Berthet E, Routhier E, Raj S, Thierry A, et al.
J Mol Biol
. 2022 Feb;
434(7):167497.
PMID: 35189129
The artificial 601 DNA sequence is often used to constrain the position of nucleosomes on a DNA molecule in vitro. Although the ability of the 147 base pair sequence to...