Julien Laffaire
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Explore the profile of Julien Laffaire including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1103
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0
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Recent Articles
1.
Boussicault L, Laffaire J, Schmitt P, Rinaudo P, Callizot N, Nabirotchkin S, et al.
J Neurosci Res
. 2020 Aug;
98(12):2435-2450.
PMID: 32815196
There is currently no therapy impacting the course of amyotrophic lateral sclerosis (ALS). The only approved treatments are riluzole and edaravone, but their efficacy is modest and short-lasting, highlighting the...
2.
Prukop T, Wernick S, Boussicault L, Ewers D, Jager K, Adam J, et al.
J Neurosci Res
. 2020 Jun;
98(10):1933-1952.
PMID: 32588471
Charcot-Marie-Tooth disease 1 A (CMT1A) is caused by an intrachromosomal duplication of the gene encoding for PMP22 leading to peripheral nerve dysmyelination, axonal loss, and progressive muscle weakness. No therapy...
3.
Hajj R, Milet A, Toulorge D, Cholet N, Laffaire J, Foucquier J, et al.
Sci Rep
. 2015 Nov;
5:16084.
PMID: 26542636
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic nigrostriatal neurons but which involves the loss of additional neurotransmitter pathways. Mono- or polytherapeutic interventions in...
4.
Chumakov I, Milet A, Cholet N, Primas G, Boucard A, Pereira Y, et al.
Orphanet J Rare Dis
. 2014 Dec;
9:201.
PMID: 25491744
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and motor peripheral neuropathy. It is caused by PMP22 overexpression which leads to defects of peripheral myelination, loss of...
5.
Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, et al.
Clin Cancer Res
. 2014 Sep;
20(22):5777-86.
PMID: 25189482
Purpose: The basaloid carcinoma (pure) and the (mixed) basaloid variant of lung squamous cell carcinoma (SCC) have a dismal prognosis but their underlying specific molecular characteristics remain obscure and no...
6.
Laffaire J, Di Stefano A, Chinot O, Idbaih A, Gallego Perez-Larraya J, Marie Y, et al.
Biomed Res Int
. 2014 May;
2014:282815.
PMID: 24804210
Background: We performed a retrospective study to assess whether the initial molecular characteristics of glioblastomas (GBMs) were associated with the response to the bevacizumab/irinotecan chemotherapy regimen given at recurrence. Results:...
7.
Rousseaux S, Debernardi A, Jacquiau B, Vitte A, Vesin A, Nagy-Mignotte H, et al.
Sci Transl Med
. 2013 May;
5(186):186ra66.
PMID: 23698379
Activation of normally silent tissue-specific genes and the resulting cell "identity crisis" are the unexplored consequences of malignant epigenetic reprogramming. We designed a strategy for investigating this reprogramming, which consisted...
8.
Fouret R, Laffaire J, Hofman P, Beau-Faller M, Mazieres J, Validire P, et al.
Clin Cancer Res
. 2012 Aug;
18(20):5606-16.
PMID: 22914773
Purpose: To identify genetic changes that could drive cancer pathogenesis in never and ever smokers with lung adenocarcinoma. Experimental Design: We analyzed the copy number and gene expression profiles of...
9.
Job B, Bernheim A, Beau-Faller M, Camilleri-Broet S, Girard P, Hofman P, et al.
PLoS One
. 2010 Dec;
5(12):e15145.
PMID: 21151896
Background: Lung cancer in never smokers would rank as the seventh most common cause of cancer death worldwide. Methods And Findings: We performed high-resolution array comparative genomic hybridization analysis of...
10.
Laffaire J, Everhard S, Idbaih A, Criniere E, Marie Y, De Reynies A, et al.
Neuro Oncol
. 2010 Oct;
13(1):84-98.
PMID: 20926426
Extensive genomic and gene expression studies have been performed in gliomas, but the epigenetic alterations that characterize different subtypes of gliomas remain largely unknown. Here, we analyzed the methylation patterns...