Julien Douet
Overview
Explore the profile of Julien Douet including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
594
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Recent Articles
1.
Desmurget C, Perilleux A, Souquet J, Borth N, Douet J
J Biotechnol
. 2024 Jun;
392:11-24.
PMID: 38852681
Biomarkers are valuable tools in clinical research where they allow to predict susceptibility to diseases, or response to specific treatments. Likewise, biomarkers can be extremely useful in the biomanufacturing of...
2.
Desmurget C, Frentzel J, Strembitska A, Sobkowiak K, Perilleux A, Souquet J, et al.
Biotechnol J
. 2024 May;
19(5):e2300488.
PMID: 38803036
Improving current cell line development workflows can either focus on increasing the specific productivity of the cell lines or shortening timelines to reach the clinic as fast as possible. In...
3.
Lo Re O, Douet J, Buschbeck M, Fusilli C, Pazienza V, Panebianco C, et al.
Epigenetics
. 2018 Sep;
13(8):829-845.
PMID: 30165787
Hepatocellular carcinomas (HCCs) contain a sub-population of cancer stem cells (CSCs) that are responsible for tumor relapse, metastasis, and chemoresistance. We recently showed that loss of macroH2A1, a variant of...
4.
Posavec Marjanovic M, Hurtado-Bages S, Lassi M, Valero V, Malinverni R, Delage H, et al.
Nat Struct Mol Biol
. 2017 Oct;
24(11):902-910.
PMID: 28991266
Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD-derived metabolites. Here we...
5.
Lo Re O, Fusilli C, Rappa F, Van Haele M, Douet J, Pindjakova J, et al.
Hepatology
. 2017 Sep;
67(2):636-650.
PMID: 28913935
Hepatocellular carcinomas (HCC) contain a subpopulation of cancer stem cells (CSCs), which exhibit stem cell-like features and are responsible for tumor relapse, metastasis, and chemoresistance. The development of effective treatments...
6.
Douet J, Corujo D, Malinverni R, Renauld J, Sansoni V, Posavec Marjanovic M, et al.
J Cell Sci
. 2017 Mar;
130(9):1570-1582.
PMID: 28283545
Genetic loss-of-function studies on development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown...
7.
Cantarino N, Musulen E, Valero V, Peinado M, Perucho M, Moreno V, et al.
Mol Cancer Res
. 2016 Jun;
14(9):841-8.
PMID: 27280713
Unlabelled: Peptidyl arginine deiminases (PADI) are a family of enzymes that catalyze the poorly understood posttranslational modification converting arginine residues into citrullines. In this study, the role of PADIs in...
8.
Cantarino N, Fernandez-Figueras M, Valero V, Musulen E, Malinverni R, Granada I, et al.
Int J Cancer
. 2016 Apr;
139(5):1106-16.
PMID: 27074337
Squamous cell carcinomas have a range of histopathological manifestations. The parameters that determine this clinically observed heterogeneity are not fully understood. Here, we report the generation of a cell culture...
9.
Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben J, et al.
Cancer Res
. 2016 Jan;
76(3):594-606.
PMID: 26772755
Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC). Cellular senescence contributes to age-related tissue dysfunction, but the epigenetic basis underlying drug-induced senescence remains...
10.
Cong R, Das S, Douet J, Wong J, Buschbeck M, Mongelard F, et al.
Nucleic Acids Res
. 2013 Sep;
42(1):181-92.
PMID: 24071584
The regulation of ribosomal DNA transcription is an important step for the control of cell growth. Epigenetic marks such as DNA methylation and posttranslational modifications of canonical histones have been...