Julie P I Welburn
Overview
Explore the profile of Julie P I Welburn including associated specialties, affiliations and a list of published articles.
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28
Citations
1014
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Recent Articles
1.
Liu H, Welburn J
Open Biol
. 2024 Jun;
14(6):240041.
PMID: 38835242
Platelets are blood cells derived from megakaryocytes that play a central role in regulating haemostasis and vascular integrity. The microtubule cytoskeleton of megakaryocytes undergoes a critical dynamic reorganization during cycles...
2.
Dodd D, Mechaussier S, Yeyati P, McPhie F, Anderson J, Khoo C, et al.
Science
. 2024 Apr;
384(6694):eadf5489.
PMID: 38662826
Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type- and context-specific microtubule structures...
3.
Weber J, Legal T, Lezcano A, Gluszek-Kustusz A, Paterson C, Eibes S, et al.
Curr Biol
. 2024 Feb;
34(5):1133-1141.e4.
PMID: 38354735
The outer corona plays an essential role at the onset of mitosis by expanding to maximize microtubule attachment to kinetochores. The low-density structure of the corona forms through the expansion...
4.
Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations
Attard T, Welburn J, Marsh J
PLoS Comput Biol
. 2022 Oct;
18(10):e1010611.
PMID: 36206299
Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β proteins that comprise microtubules have been associated with various...
5.
McHugh T, Welburn J
J Cell Sci
. 2022 May;
136(5).
PMID: 35502670
The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule...
6.
Craske B, Legal T, Welburn J
Open Biol
. 2022 Mar;
12(3):210389.
PMID: 35259950
CENP-E is a large kinesin motor protein which plays pivotal roles in mitosis by facilitating chromosome capture and alignment, and promoting microtubule flux in the spindle. So far, it has...
7.
Legal T, Hayward D, Gluszek-Kustusz A, Blackburn E, Spanos C, Rappsilber J, et al.
J Cell Sci
. 2020 Jul;
133(16).
PMID: 32665320
During cell division, misaligned chromosomes are captured and aligned by motors before their segregation. The CENP-E motor is recruited to polar unattached kinetochores to facilitate chromosome alignment. The spindle checkpoint...
8.
Craske B, Welburn J
Essays Biochem
. 2020 Apr;
64(2):313-324.
PMID: 32347304
Chromosome alignment and biorientation is essential for mitotic progression and genomic stability. Most chromosomes align at the spindle equator in a motor-independent manner. However, a subset of polar kinetochores fail...
9.
Bergendahl L, Gerasimavicius L, Miles J, Macdonald L, Wells J, Welburn J, et al.
Protein Sci
. 2019 Jun;
28(8):1400-1411.
PMID: 31219644
Many human genetic disorders are caused by mutations in protein-coding regions of DNA. Taking protein structure into account has therefore provided key insight into the molecular mechanisms underlying human genetic...
10.