Toni McHugh
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Explore the profile of Toni McHugh including associated specialties, affiliations and a list of published articles.
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11
Citations
122
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Recent Articles
1.
Parashara P, Medina-Pritchard B, Abad M, Sotelo-Parrilla P, Thamkachy R, Grundei D, et al.
Science
. 2024 Sep;
385(6713):1098-1104.
PMID: 39236175
Accurate chromosome segregation requires the attachment of microtubules to centromeres, epigenetically defined by the enrichment of CENP-A nucleosomes. During DNA replication, CENP-A nucleosomes undergo dilution. To preserve centromere identity, correct...
2.
Pantier R, Brown M, Han S, Paton K, Meek S, Montavon T, et al.
Nat Commun
. 2024 May;
15(1):3880.
PMID: 38719804
Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation. This interpretation has been reinforced by the observation that heterochromatin,...
3.
Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis
Gluszek-Kustusz A, Craske B, Legal T, McHugh T, Welburn J
EMBO J
. 2023 Aug;
42(21):e113647.
PMID: 37592895
During mitosis, spindle architecture alters as chromosomes segregate into daughter cells. The microtubule crosslinker protein regulator of cytokinesis 1 (PRC1) is essential for spindle stability, chromosome segregation and completion of...
4.
Wu W, McHugh T, Kelly D, Pidoux A, Allshire R
Curr Biol
. 2022 Jul;
32(14):3121-3136.e6.
PMID: 35830853
The establishment of centromere-specific CENP-A chromatin is influenced by epigenetic and genetic processes. Central domain sequences from fission yeast centromeres are preferred substrates for CENP-A incorporation, but their use is...
5.
Abad M, Gupta T, Hadders M, Meppelink A, Wopken J, Blackburn E, et al.
J Cell Biol
. 2022 Jul;
221(8).
PMID: 35776132
Centromere association of the chromosomal passenger complex (CPC; Borealin-Survivin-INCENP-Aurora B) and Sgo1 is crucial for chromosome biorientation, a process essential for error-free chromosome segregation. Phosphorylated histone H3 Thr3 (H3T3ph; directly...
6.
McHugh T, Welburn J
J Cell Sci
. 2022 May;
136(5).
PMID: 35502670
The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule...
7.
McHugh T, Zou J, Volkov V, Bertin A, Talapatra S, Rappsilber J, et al.
J Cell Sci
. 2018 Dec;
132(4).
PMID: 30578316
Kinesin-13 motors regulate precise microtubule dynamics and limit microtubule length throughout metazoans by depolymerizing microtubule ends. Recently, the kinesin-13 motor family member MCAK (also known Kif2C) has been proposed to...
8.
McHugh T, Drechsler H, McAinsh A, Carter N, Cross R
Mol Biol Cell
. 2018 May;
29(13):1743-1752.
PMID: 29771628
Kif15 is a kinesin-12 that contributes critically to bipolar spindle assembly in humans. Here we use force-ramp experiments in an optical trap to probe the mechanics of single Kif15 molecules...
9.
Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning
McHugh T, Gluszek A, Welburn J
J Cell Biol
. 2018 Apr;
217(7):2403-2416.
PMID: 29661912
Mitotic spindle positioning specifies the plane of cell division during anaphase. Spindle orientation and positioning are therefore critical to ensure symmetric division in mitosis and asymmetric division during development. The...
10.
McHugh T, Welburn J
J Cell Biol
. 2017 Mar;
216(4):855-857.
PMID: 28320823
Dynein removes the checkpoint proteins from kinetochores once chromosomes are bioriented. In this issue, Gama et al. (2017. https://doi.org/10.1083/jcb.201610108) and Mosalaganti et al. (2017. https://doi.org/10.1083/jcb.201611060) reveal the molecular basis for...