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» Authors » Juliane Sachsenweger

Juliane Sachsenweger

Explore the profile of Juliane Sachsenweger including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 4
Citations 59
Followers 0
Related Specialties
General Medicine
Biochemistry
Cell Biology
Top 10 Co-Authors
Helmut Pospiech
Lisa Wiesmuller
Katri Pylkas
Robert Winqvist
Hellevi Peltoketo
Christopher Schroeder
Kerstin Borgmann
Pola Smirin-Yosef
Hanna Tuppurainen
Frank Grosse
Published In
Nucleic Acids Res
Cell Death Dis
J Clin Endocrinol Metab
Hum Mol Genet
Affiliations
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Recent Articles
1.
ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients
Sachsenweger J, Jansche R, Merk T, Heitmeir B, Deniz M, Faust U, et al.
Cell Death Dis . 2023 May; 14(5):328. PMID: 37198153
It has been well-established that mutations in BRCA1 and BRCA2, compromising functions in DNA double-strand break repair (DSBR), confer hereditary breast and ovarian cancer risk. Importantly, mutations in these genes...
2.
BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells
Bose M, Sachsenweger J, Laurila N, Parplys A, Willmann J, Jungwirth J, et al.
Hum Mol Genet . 2019 Oct; 28(24):4148-4160. PMID: 31630195
Whilst heterozygous germline mutations in the ABRAXAS1 gene have been associated with a hereditary predisposition to breast cancer, their effect on promoting tumourigenesis at the cellular level has not been...
3.
A Biallelic Mutation in the Homologous Recombination Repair Gene SPIDR Is Associated With Human Gonadal Dysgenesis
Smirin-Yosef P, Zuckerman-Levin N, Tzur S, Granot Y, Cohen L, Sachsenweger J, et al.
J Clin Endocrinol Metab . 2016 Dec; 102(2):681-688. PMID: 27967308
Context: Primary ovarian insufficiency (POI) is caused by ovarian follicle depletion or follicle dysfunction, characterized by amenorrhea with elevated gonadotropin levels. The disorder presents as absence of normal progression of...
4.
The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding
Keller H, Kiosze K, Sachsenweger J, Haumann S, Ohlenschlager O, Nuutinen T, et al.
Nucleic Acids Res . 2014 Oct; 42(20):12614-27. PMID: 25336622
Human RecQL4 belongs to the ubiquitous RecQ helicase family. Its N-terminal region represents the only homologue of the essential DNA replication initiation factor Sld2 of Saccharomyces cerevisiae, and also participates...