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Juliana Wambua

Explore the profile of Juliana Wambua including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 1073
Followers 0
Related Specialties
General Medicine
Science
Infectious Diseases
Top 10 Co-Authors
Philip Bejon
Kevin Marsh
George Nyangweso
Ally Olotu
Patricia Njuguna
Gregory Fegan
Thomas N Williams
Francis M Ndungu
Edna Ogada
Mainga Hamaluba
Published In
PLoS One
BMC Med
Wellcome Open Res
J Infect Dis
N Engl J Med
Affiliations
Soon will be listed here.
Recent Articles
1.
Low frequency of deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya
Okanda D, Ndwiga L, Osoti V, Achieng N, Wambua J, Ngetsa C, et al.
Front Epidemiol . 2024 Mar; 3:1083114. PMID: 38455911
There is a growing concern for malaria control in the Horn of Africa region due to the spread and rise in the frequency of Histidine-rich Protein (hrp) 2 and 3...
2.
Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected
Kimenyi K, Akinyi M, Mwikali K, Gilmore T, Mwangi S, Omer E, et al.
BMC Infect Dis . 2024 Jan; 24(1):140. PMID: 38287287
Background: Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance...
3.
Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host diversity throughout treatment in a clinical drug trial
Wamae K, Ndwiga L, Kharabora O, Kimenyi K, Osoti V, de Laurent Z, et al.
Wellcome Open Res . 2023 Jul; 7:95. PMID: 37456906
Introduction: Antimalarial therapeutic efficacy studies are routinely conducted in malaria-endemic countries to assess the effectiveness of antimalarial treatment strategies. Targeted amplicon sequencing (AmpSeq) uniquely identifies and quantifies genetically distinct parasites...
4.
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria
Odera D, Tuju J, Mwai K, Nkumama I, Furle K, Chege T, et al.
Sci Transl Med . 2023 Feb; 15(682):eabn5993. PMID: 36753561
Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ...
5.
Undertaking Community Engagement for a Controlled Human Malaria Infection Study in Kenya: Approaches and Lessons Learnt
Mumba N, Njuguna P, Chi P, Marsh V, Awuor E, Hamaluba M, et al.
Front Public Health . 2022 May; 10:793913. PMID: 35570883
Human infection studies (HIS) involve deliberately infecting healthy volunteers with disease-causing pathogens under controlled conditions. These studies are "controlled" by way of using specific types of pathogens, including dose, and...
6.
Cessation of exclusive breastfeeding and seasonality, but not small intestinal bacterial overgrowth, are associated with environmental enteric dysfunction: A birth cohort study amongst infants in rural Kenya
Crane R, Parker E, Fleming S, Gwela A, Gumbi W, Ngoi J, et al.
EClinicalMedicine . 2022 May; 47:101403. PMID: 35497062
Background: Environmental Enteric Dysfunction (EED) is a chronic intestinal inflammatory disorder of unclear aetiology prevalent amongst children in low-income settings and associated with stunting. We aimed to characterise development of...
7.
Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature Gametocytes
Muthui M, Takashima E, Omondi B, Kinya C, Muasya W, Nagaoka H, et al.
Front Cell Infect Microbiol . 2021 Dec; 11:774537. PMID: 34869075
Introduction: Naturally acquired immune responses against antigens expressed on the surface of mature gametocytes develop in individuals living in malaria-endemic areas. Evidence suggests that such anti-gametocyte immunity can block the...
8.
Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
Mugo R, Mwai K, Mwacharo J, Shee F, Musyoki J, Wambua J, et al.
Malar J . 2021 Dec; 20(1):452. PMID: 34856981
Background: RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Here,...
9.
Arterolane-piperaquine-mefloquine versus arterolane-piperaquine and artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial
Hamaluba M, van der Pluijm R, Weya J, Njuguna P, Ngama M, Kalume P, et al.
Lancet Infect Dis . 2021 Jun; 21(10):1395-1406. PMID: 34111412
Background: Triple antimalarial combination therapies combine potent and rapidly cleared artemisinins or related synthetic ozonides, such as arterolane, with two, more slowly eliminated partner drugs to reduce the risk of...
10.
Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype
Aye R, Sutton H, Nduati E, Kai O, Mwacharo J, Musyoki J, et al.
Eur J Immunol . 2020 Mar; 50(8):1187-1194. PMID: 32222961
Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag,...