Julian R Homburger
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Explore the profile of Julian R Homburger including associated specialties, affiliations and a list of published articles.
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14
Citations
887
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0
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Recent Articles
1.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
2.
Haas M, Pirruccello J, Friedman S, Wang M, Emdin C, Ajmera V, et al.
Cell Genom
. 2021 Dec;
1(3).
PMID: 34957434
Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease and cardiometabolic diseases but often remains undiagnosed in clinical practice because of the need for...
3.
Ioannidis A, Blanco-Portillo J, Sandoval K, Hagelberg E, Barberena-Jonas C, Hill A, et al.
Nature
. 2021 Sep;
597(7877):522-526.
PMID: 34552258
Polynesia was settled in a series of extraordinary voyages across an ocean spanning one third of the Earth, but the sequences of islands settled remain unknown and their timings disputed....
4.
McGee R, Homburger J, Williams H, Bergstrom C, Zhou A
Proc Natl Acad Sci U S A
. 2021 Sep;
118(39).
PMID: 34518375
Reopening schools is an urgent priority as the COVID-19 pandemic drags on. To explore the risks associated with returning to in-person learning and the value of mitigation measures, we developed...
5.
Fahed A, Wang M, Homburger J, Patel A, Bick A, Neben C, et al.
Nat Commun
. 2020 Aug;
11(1):3635.
PMID: 32820175
Genetic variation can predispose to disease both through (i) monogenic risk variants that disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that involves many variants...
6.
Ioannidis A, Blanco-Portillo J, Sandoval K, Hagelberg E, Miquel-Poblete J, Moreno-Mayar J, et al.
Nature
. 2020 Jul;
583(7817):572-577.
PMID: 32641827
The possibility of voyaging contact between prehistoric Polynesian and Native American populations has long intrigued researchers. Proponents have pointed to the existence of New World crops, such as the sweet...
7.
Homburger J, Neben C, Mishne G, Zhou A, Kathiresan S, Khera A
Genome Med
. 2019 Nov;
11(1):74.
PMID: 31771638
Background: Inherited susceptibility to common, complex diseases may be caused by rare, pathogenic variants ("monogenic") or by the cumulative effect of numerous common variants ("polygenic"). Comprehensive genome interpretation should enable...
8.
de la Fuente C, Avila-Arcos M, Galimany J, Carpenter M, Homburger J, Blanco A, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(17):E4006-E4012.
PMID: 29632188
Patagonia was the last region of the Americas reached by humans who entered the continent from Siberia ∼15,000-20,000 y ago. Despite recent genomic approaches to reconstruct the continental evolutionary history,...
9.
Schroeder H, Sikora M, Gopalakrishnan S, Cassidy L, Delser P, Velasco M, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(10):2341-2346.
PMID: 29463742
The Caribbean was one of the last parts of the Americas to be settled by humans, but how and when the islands were first occupied remains a matter of debate....
10.
McConnell M, Shcherbina A, Pavlovic A, Homburger J, Goldfeder R, Waggot D, et al.
JAMA Cardiol
. 2016 Dec;
2(1):67-76.
PMID: 27973671
Importance: Studies have established the importance of physical activity and fitness, yet limited data exist on the associations between objective, real-world physical activity patterns, fitness, sleep, and cardiovascular health. Objectives:...