Juha M T Hyttinen
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Explore the profile of Juha M T Hyttinen including associated specialties, affiliations and a list of published articles.
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37
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1610
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Recent Articles
1.
Hyttinen J, Koskela A, Blasiak J, Kaarniranta K
Acta Ophthalmol
. 2024 Aug;
102(7):759-772.
PMID: 39087629
Age-related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE),...
2.
Hyttinen J, Blasiak J, Kaarniranta K
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768958
Age-related macular degeneration (AMD) is an ever-increasing, insidious disease which reduces the quality of life of millions of elderly people around the world. AMD is characterised by damage to the...
3.
Tamminen T, Koskela A, Toropainen E, Gurubaran I, Winiarczyk M, Liukkonen M, et al.
Oxid Med Cell Longev
. 2021 Dec;
2021:8028427.
PMID: 34917233
Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age-related macular degeneration. We have previously shown an effective age-related macular degeneration...
4.
Blasiak J, Hyttinen J, Szczepanska J, Pawlowska E, Kaarniranta K
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502084
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with poorly known pathogenesis and lack of effective treatment. Age and family history are the...
5.
Gurubaran I, Helotera H, Marry S, Koskela A, Hyttinen J, Paterno J, et al.
Biology (Basel)
. 2021 Aug;
10(7).
PMID: 34356477
Aging-associated chronic oxidative stress and inflammation are known to be involved in various diseases, e.g., age-related macular degeneration (AMD). Previously, we reported the presence of dry AMD-like signs, such as...
6.
Blasiak J, Koskela A, Pawlowska E, Liukkonen M, Ruuth J, Toropainen E, et al.
Int J Mol Sci
. 2021 Feb;
22(4).
PMID: 33567500
Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population. In our previous studies, we found that deficiencies in the nuclear factor, erythroid...
7.
Hyttinen J, Blasiak J, Felszeghy S, Kaarniranta K
Ageing Res Rev
. 2021 Jan;
67:101260.
PMID: 33516915
Age-related macular degeneration (AMD) is a progressive sight-impairing disease of the elderly. The pathogenic mechanisms of AMD are not well understood although both genetic and many environmental factors have been...
8.
Paterno J, Koskela A, Hyttinen J, Vattulainen E, Synowiec E, Tuuminen R, et al.
Genes (Basel)
. 2020 Nov;
11(11).
PMID: 33172148
Age-related macular degeneration is an eye disease that is the main cause of legal blindness in the elderly in developed countries. Despite this, its pathogenesis is not completely known, and...
9.
Korhonen E, Bisevac J, Hyttinen J, Piippo N, Hytti M, Kaarniranta K, et al.
Invest Ophthalmol Vis Sci
. 2020 Apr;
61(4):7.
PMID: 32271889
Purpose: The cornea is continually exposed to highly energetic solar UV-B (280-320 nm). Our aim was to investigate whether UV-B triggers the activation of NLRP3 inflammasomes and the production of...
10.
Korhonen E, Piippo N, Hytti M, Hyttinen J, Kaarniranta K, Kauppinen A
FASEB J
. 2020 Mar;
34(5):6437-6448.
PMID: 32190930
DNA damage accumulates in aged postmitotic retinal pigment epithelium (RPE) cells, a phenomenon associated with the development of age-related macular degeneration. In this study, we have experimentally induced DNA damage...