Judith L Campbell
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Explore the profile of Judith L Campbell including associated specialties, affiliations and a list of published articles.
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59
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2812
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Recent Articles
1.
Liu W, Polaczek P, Roubal I, Meng Y, Choe W, Caron M, et al.
Nucleic Acids Res
. 2023 Aug;
51(17):9144-9165.
PMID: 37526271
FANCD2 protein, a key coordinator and effector of the interstrand crosslink repair pathway, is also required to prevent excessive nascent strand degradation at hydroxyurea-induced stalled forks. The RAD51 recombinase has...
2.
Sun H, Lu Z, Singh A, Zhou Y, Zheng E, Zhou M, et al.
Science
. 2021 Dec;
374(6572):1252-1258.
PMID: 34855483
How cells with DNA replication defects acquire mutations that allow them to escape apoptosis under environmental stress is a long-standing question. Here, we report that an error-prone Okazaki fragment maturation...
3.
Zheng L, Meng Y, Campbell J, Shen B
Nucleic Acids Res
. 2019 Nov;
48(1):16-35.
PMID: 31754720
DNA2 nuclease/helicase is a structure-specific nuclease, 5'-to-3' helicase, and DNA-dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki fragment maturation, replication of 'difficult-to-replicate' DNA regions, end resection,...
4.
Liu L, Zhang Y, Zhang J, Wang J, Cao Q, Li Z, et al.
Cell Mol Life Sci
. 2019 Nov;
77(15):3041-3058.
PMID: 31728581
The pre-initiation complex (pre-IC) has been proposed for two decades as an intermediate right before the maturation of the eukaryotic DNA replication fork. However, its existence and biochemical nature remain...
5.
Meng Y, Liu C, Shen L, Zhou M, Liu W, Kowolik C, et al.
Nucleic Acids Res
. 2019 Jun;
47(14):7564-7579.
PMID: 31216032
The multifunctional human DNA2 (hDNA2) nuclease/helicase is required to process DNA ends for homology-directed recombination repair (HDR) and to counteract replication stress. To participate in these processes, hDNA2 must localize...
6.
Aiello F, Palma A, Malacaria E, Zheng L, Campbell J, Shen B, et al.
Nucleic Acids Res
. 2019 May;
47(13):6796-6810.
PMID: 31114910
Stabilization of stalled replication forks prevents excessive fork reversal or degradation, which can undermine genome integrity. The WRN protein is unique among the other human RecQ family members to possess...
7.
Campbell J, Li H
Nat Struct Mol Biol
. 2017 Dec;
24(12):1007-1008.
PMID: 29215638
No abstract available.
8.
Zhang Z, Zhang J, Cao Q, Campbell J, Lou H
Cell Cycle
. 2017 Nov;
17(1):64-72.
PMID: 29157061
DNA replication checkpoint (Mec1-Mrc1-Rad53 in budding yeast) is an evolutionarily conserved surveillance system to ensure proper DNA replication and genome stability in all eukaryotes. Compared to its well-known function as...
9.
Dmowski M, Rudzka J, Campbell J, Jonczyk P, Fijalkowska I
PLoS Genet
. 2017 Jan;
13(1):e1006572.
PMID: 28107343
To preserve genome integrity, the S-phase checkpoint senses damaged DNA or nucleotide depletion and when necessary, arrests replication progression and delays cell division. Previous studies, based on two pol2 mutants...
10.
Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, et al.
EBioMedicine
. 2016 May;
6:73-86.
PMID: 27211550
Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival. Therefore, we hypothesized that blocking...