Juan J Lafaille
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Explore the profile of Juan J Lafaille including associated specialties, affiliations and a list of published articles.
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66
Citations
8538
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Recent Articles
1.
Samanta J, Silva H, Lafaille J, Salzer J
Sci Data
. 2021 Oct;
8(1):278.
PMID: 34711861
In the adult mammalian brain, Gli1 expressing neural stem cells reside in the subventricular zone and their progeny are recruited to sites of demyelination in the white matter where they...
2.
Silva H, Kitoko J, Queiroz C, Kroehling L, Matheis F, Yang K, et al.
Sci Immunol
. 2021 Oct;
6(64):eabg7506.
PMID: 34597123
Macrophages are an essential part of tissue development and physiology. Perivascular macrophages have been described in tissues and appear to play a role in development and disease processes, although it...
3.
He Z, Chen L, Catalan-Dibene J, Bongers G, Faith J, Suebsuwong C, et al.
Cell Metab
. 2021 May;
33(7):1358-1371.e5.
PMID: 33989521
Both genetic predisposition and environmental factors appear to play a role in inflammatory bowel disease (IBD) development. Genetic studies in humans have linked the interleukin (IL)-23 signaling pathway with IBD,...
4.
Huang L, Lafaille J, Yang G
Dev Neurobiol
. 2021 May;
81(5):736-745.
PMID: 33949123
Cognitive impairment is often observed in multiple sclerosis and its animal models, experimental autoimmune encephalomyelitis (EAE). Using mice with immunization-induced EAE, we have previously shown that the stability of cortical...
5.
Xiong H, Mancini M, Gobert M, Shen S, Furtado G, Lira S, et al.
Theranostics
. 2021 Jan;
11(4):1594-1608.
PMID: 33408769
The Notch pathway is highly active in almost all patients with T-cell acute lymphoblastic leukemia (T-ALL), but the implication of Notch ligands in T-ALL remains underexplored. We used a genetic...
6.
Tan I, Arifa R, Rallapalli H, Kana V, Lao Z, Sanghrajka R, et al.
Oncogene
. 2020 Nov;
40(2):396-407.
PMID: 33159168
The immune microenvironment of tumors can play a critical role in promoting or inhibiting tumor progression depending on the context. We present evidence that tumor-associated macrophages/microglia (TAMs) can promote tumor...
7.
Wu L, Hollinshead K, Hao Y, Au C, Kroehling L, Ng C, et al.
Cell
. 2020 Jul;
182(3):641-654.e20.
PMID: 32615085
Targeting glycolysis has been considered therapeutically intractable owing to its essential housekeeping role. However, the context-dependent requirement for individual glycolytic steps has not been fully explored. We show that CRISPR-mediated...
8.
Sharma M, Schlegel M, Afonso M, Brown E, Rahman K, Weinstock A, et al.
Circ Res
. 2020 Apr;
127(3):335-353.
PMID: 32336197
Rationale: Regression of atherosclerosis is an important clinical goal; however, the pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques are poorly understood. Regulatory T cells (Tregs)...
9.
Garre J, Silva H, Lafaille J, Yang G
Nat Commun
. 2020 Apr;
11(1):1784.
PMID: 32286307
Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique...
10.
Silva H, Bafica A, Rodrigues-Luiz G, Chi J, Santos P, Reis B, et al.
J Exp Med
. 2019 Mar;
216(4):786-806.
PMID: 30862706
Tissue-resident macrophages are the most abundant immune cell population in healthy adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabolic syndrome. Here,...