Dan R Littman
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Explore the profile of Dan R Littman including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Britton G, Mogno I, Chen-Liaw A, Plitt T, Helmus D, Bongers G, et al.
bioRxiv
. 2025 Jan;
PMID: 39868147
We examine disease-specific and cross-disease functions of the human gut microbiome by colonizing germ-free mice, at risk for inflammatory arthritis, colitis, or neuroinflammation, with over 100 human fecal microbiomes from...
2.
Nguyen H, Talbot J, Li D, Raghavan V, Littman D
Hepatol Commun
. 2025 Jan;
8(11.
PMID: 39761015
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD) is a major driver of cirrhosis and liver-related mortality. However, therapeutic options for MASLD, including prevention of liver steatosis,...
3.
Kedmi R, Littman D
Immunity
. 2024 Oct;
57(10):2269-2279.
PMID: 39383844
The immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate, non-inflammatory responses. This process requires antigen-presenting cells (APCs) that induce...
4.
Najar T, Hao Y, Hao Y, Romero-Meza G, Dolynuk A, Littman D
bioRxiv
. 2024 Aug;
PMID: 39185202
Therapies that harness the immune system to target and eliminate tumor cells have revolutionized cancer care. Immune checkpoint blockade (ICB), which boosts the anti-tumor immune response by inhibiting negative regulators...
5.
Varghese A, Gusarov I, Gamallo-Lana B, Dolgonos D, Mankan Y, Shamovsky I, et al.
bioRxiv
. 2024 Aug;
PMID: 39131293
Forty percent of the US population and 1 in 6 individuals worldwide are obese, and the incidence of this disease is surging globally. Various dietary interventions, including carbohydrate and fat...
6.
Fu L, Upadhyay R, Pokrovskii M, Chen F, Romero-Meza G, Griesemer A, et al.
bioRxiv
. 2024 Aug;
PMID: 39091750
The gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microbes with potential to induce adaptive immune responses. Peripherally induced T regulatory (pTreg) cells are essential for...
7.
Blum J, Kong R, Schulman E, Chen F, Upadhyay R, Romero-Meza G, et al.
bioRxiv
. 2024 Jun;
PMID: 38853977
Food antigens elicit immune tolerance through the action of regulatory T cells (Tregs) in the intestine. Although antigens that trigger common food allergies are known, the epitopes that mediate tolerance...
8.
Philips E, Liu J, Kvalvaag A, Morch A, Tocheva A, Ng C, et al.
Sci Immunol
. 2024 Mar;
9(93):eade6256.
PMID: 38457513
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune...
9.
Zhang B, Upadhyay R, Hao Y, Samanovic M, Herati R, Blair J, et al.
Nat Immunol
. 2023 Sep;
24(10):1725-1734.
PMID: 37735591
The immune response to SARS-CoV-2 antigen after infection or vaccination is defined by the durable production of antibodies and T cells. Population-based monitoring typically focuses on antibody titer, but there...
10.
Mesa K, OConnor K, Ng C, Salvatore S, Salvatore S, Dolynuk A, et al.
bioRxiv
. 2023 Sep;
PMID: 37662387
All mammalian organs depend upon resident macrophage populations to coordinate repair processes and facilitate tissue-specific functions. Recent work has established that functionally distinct macrophage populations reside in discrete tissue niches...