Juan F Santana
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Explore the profile of Juan F Santana including associated specialties, affiliations and a list of published articles.
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10
Citations
86
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Recent Articles
1.
Spector B, Santana J, Pufall M, Price D
Nucleic Acids Res
. 2024 Sep;
52(18):e88.
PMID: 39248105
Recently, we introduced a chromatin immunoprecipitation (ChIP) technique utilizing the human DNA Fragmentation Factor (DFF) to digest the DNA prior to immunoprecipitation (DFF-ChIP) that provides the precise location of transcription...
2.
Mullen N, Shukla S, Thakur R, Kollala S, Wang D, Chaika N, et al.
Elife
. 2024 Jul;
12.
PMID: 38973593
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an...
3.
Santana J, Spector B, Suarez G, Luse D, Price D
Nucleic Acids Res
. 2024 Jan;
52(6):2977-2994.
PMID: 38197272
Many factors control the elongation phase of transcription by RNA polymerase II (Pol II), a process that plays an essential role in regulating gene expression. We utilized cells expressing degradation...
4.
Wu S, Lai H, Sanjib Banerjee N, Ma Z, Santana J, Wei S, et al.
Mol Cell
. 2023 Dec;
84(2):202-220.e15.
PMID: 38103559
Compounds binding to the bromodomains of bromodomain and extra-terminal (BET) family proteins, particularly BRD4, are promising anticancer agents. Nevertheless, side effects and drug resistance pose significant obstacles in BET-based therapeutics...
5.
Kartha N, Gianopulos J, Schrank Z, Cavender S, Dobersch S, Kynnap B, et al.
Sci Transl Med
. 2023 May;
15(694):eabn9674.
PMID: 37134154
Pancreatic ductal adenocarcinoma (PDAC) is classified into two key subtypes, classical and basal, with basal PDAC predicting worse survival. Using in vitro drug assays, genetic manipulation experiments, and in vivo...
6.
Mullen N, Shukla S, Thakur R, Kollala S, Wang D, Chaika N, et al.
bioRxiv
. 2023 Apr;
PMID: 37066260
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an...
7.
Santana J, Collins G, Parida M, Luse D, Price D
Nucleic Acids Res
. 2022 Aug;
50(16):9127-9148.
PMID: 35947745
The effects of rapid acute depletion of components of RNA polymerase II (Pol II) general transcription factors (GTFs) that are thought to be critical for formation of preinitiation complexes (PICs)...
8.
Ball C, Parida M, Santana J, Spector B, Suarez G, Price D
Nucleic Acids Res
. 2022 Jan;
50(4):1908-1926.
PMID: 35048979
Approximately half of purified mammalian RNA polymerase II (Pol II) is associated with a tightly interacting sub-stoichiometric subunit, Gdown1. Previous studies have established that Gdown1 inhibits transcription initiation through competitive...
9.
Santana J, Parida M, Long A, Wankum J, Lilienthal A, Nukala K, et al.
Cell Rep
. 2020 Mar;
30(10):3218-3228.e5.
PMID: 32160531
Drosophila Myb (Dm-Myb) encodes a protein that plays a key role in regulation of mitotic phase genes. Here, we further refine its role in the context of a developing tissue...
10.
Seberg H, Van Otterloo E, Loftus S, Liu H, Bonde G, Sompallae R, et al.
PLoS Genet
. 2017 Mar;
13(3):e1006636.
PMID: 28249010
Mutations in the gene encoding transcription factor TFAP2A result in pigmentation anomalies in model organisms and premature hair graying in humans. However, the pleiotropic functions of TFAP2A and its redundantly-acting...