Amarnath Natarajan
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Explore the profile of Amarnath Natarajan including associated specialties, affiliations and a list of published articles.
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104
Citations
1203
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Recent Articles
1.
Azadmanesh J, Slobodnik K, Struble L, Lovelace J, Cone E, Dasgupta M, et al.
Nat Commun
. 2025 Feb;
16(1):1887.
PMID: 39987263
Human manganese superoxide dismutase (MnSOD) plays a crucial role in controlling levels of reactive oxygen species (ROS) by converting superoxide ( ) to molecular oxygen (O) and hydrogen peroxide (HO)...
2.
Schmitz E, Ridout A, Smith A, Eiken A, Skupa S, Drengler E, et al.
Biomedicines
. 2025 Jan;
12(12.
PMID: 39767763
Targeted therapies (e.g., ibrutinib) have markedly improved chronic lymphocytic leukemia (CLL) management; however, ~20% of patients experience disease relapse, suggesting the inadequate depth and durability of these front-line strategies. Moreover,...
3.
Tolosa E, Yang L, Ayers-Ringler J, Suzuki S, Mallareddy J, Schaefer-Klein J, et al.
Commun Biol
. 2024 Dec;
7(1):1719.
PMID: 39741170
Antibody-drug conjugates (ADCs) are increasingly used in clinic for multiple indications and may improve upon the activity of parental antibodies by delivering cytotoxic payloads into target cells. This activity is...
4.
Mallareddy J, Yang L, Lin W, Feathers R, Ayers-Ringler J, Tolosa E, et al.
bioRxiv
. 2024 Dec;
PMID: 39651287
Despite ongoing efforts to employ structure-based methods to discover targeted protein degraders (TPD), the prevailing strategy continues to be the synthesis of a focused set of heterobifunctional compounds and screen...
5.
Eiken A, Schmitz E, Drengler E, Smith A, Skupa S, Mohan K, et al.
Hemato
. 2024 Oct;
5(3):321-339.
PMID: 39450301
Background: B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and aberrant anti-apoptotic mechanisms (e.g., BCL2) culminating...
6.
Qiao F, Binkowski T, Broughan I, Chen W, Natarajan A, Schiltz G, et al.
Cancers (Basel)
. 2024 Sep;
16(18).
PMID: 39335149
Drug discovery historically starts with an established function, either that of compounds or proteins. This can hamper discovery of novel therapeutics. As structure determines function, we hypothesized that unique 3D...
7.
Mukthapuram P, Natarajan A
Molecules
. 2024 Aug;
29(15).
PMID: 39125017
Isatin-derived spirocyclic cores are found in several biologically active molecules. Here, we report nucleophilic domino reactions for the synthesis of α-methylene-γ-butyrolactone/lactam containing spirocyclic oxindoles. The Zn-mediated one-step reaction accommodates a...
8.
Mullen N, Shukla S, Thakur R, Kollala S, Wang D, Chaika N, et al.
Elife
. 2024 Jul;
12.
PMID: 38973593
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an...
9.
Borgstahl G, Azadmanesh J, Slobodnik K, Struble L, Cone E, Dasgupta M, et al.
Res Sq
. 2024 Jul;
PMID: 38946943
Human manganese superoxide dismutase (MnSOD) plays a crucial role in controlling levels of reactive oxygen species (ROS) by converting superoxide (O ) to molecular oxygen (O) and hydrogen peroxide (HO)...
10.
Bhat A, Mohapatra B, Luan H, Mushtaq I, Chakraborty S, Kumar S, et al.
Sci Rep
. 2024 Jun;
14(1):13523.
PMID: 38866755
While better management of loco-regional prostate cancer (PC) has greatly improved survival, advanced PC remains a major cause of cancer deaths. Identification of novel targetable pathways that contribute to tumor...