Juan Carlos Morales
Overview
Explore the profile of Juan Carlos Morales including associated specialties, affiliations and a list of published articles.
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Articles
49
Citations
596
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Recent Articles
1.
Perez-Soto M, Penalver P, Munoz-Baez P, Tolosa J, Garcia-Martinez J, Cebrian R, et al.
Molecules
. 2025 Jan;
29(24.
PMID: 39769964
G-quadruplexes (G4s) are non-canonical secondary structures that play a crucial role in the regulation of genetic expression. This study explores the interaction between G4s and a small family of oligostyrylbenzene...
2.
Callahan J, Morales J, Atherton J, Wang D, Kostic S, Bevan M
Cell Rep
. 2024 Jul;
43(8):114495.
PMID: 39068661
The subthalamic nucleus (STN) is traditionally thought to restrict movement. Lesion or prolonged STN inhibition increases movement vigor and propensity, while optogenetic excitation has opposing effects. However, STN neurons often...
3.
Perez-Soto M, Ramos-Soriano J, Penalver P, Belmonte-Reche E, OHagan M, Cucchiarini A, et al.
Eur J Med Chem
. 2024 Jul;
276:116641.
PMID: 38971047
Chagas disease is caused by the parasite Trypanosoma cruzi and affects over 7 million people worldwide. The two actual treatments, Benznidazole (Bzn) and Nifurtimox, cause serious side effects due to...
4.
Benassi A, Penalver P, Perez-Soto M, Pirota V, Freccero M, Morales J, et al.
J Med Chem
. 2024 Jun;
67(13):10643-10654.
PMID: 38924701
Several G-quadruplex nucleic acid (G4s) ligands have been developed seeking target selectivity in the past decade. Naphthalene diimide (NDI)-based compounds are particularly promising due to their biological activity and red-fluorescence...
5.
Serrano-Martinez I, Pedreno M, Castillo-Gonzalez J, Ferraz-de-Paula V, Vargas-Rodriguez P, Forte-Lago I, et al.
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38255772
Parkinson's disease (PD) is a complex disorder characterized by the impairment of the dopaminergic nigrostriatal system. PD has duplicated its global burden in the last few years, becoming the leading...
6.
Callahan J, Morales J, Atherton J, Wang D, Kostic S, Bevan M
bioRxiv
. 2023 Dec;
PMID: 38105984
The subthalamic nucleus (STN) is traditionally thought to restrict movement. Lesion or prolonged STN inhibition increases movement vigor and propensity, while ontogenetic excitation typically has opposing effects. Subthalamic and motor...
7.
Cebrian R, Lucas R, Fernandez-Cantos M, Slot K, Penalver P, Martinez-Garcia M, et al.
J Enzyme Inhib Med Chem
. 2023 Jan;
38(1):267-281.
PMID: 36600674
Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. In this work, we present a family of aminoalkyl resveratrol...
8.
Cebrian R, Li Q, Penalver P, Belmonte-Reche E, Andres-Bilbao M, Lucas R, et al.
J Nat Prod
. 2022 May;
85(6):1459-1473.
PMID: 35621995
In the era of antimicrobial resistance, the identification of new compounds with strong antimicrobial activity and the development of alternative therapies to fight drug-resistant bacteria are urgently needed. Here, we...
9.
Carrillo-Perez F, Morales J, Castillo-Secilla D, Gevaert O, Rojas I, Herrera L
J Pers Med
. 2022 Apr;
12(4).
PMID: 35455716
Differentiation between the various non-small-cell lung cancer subtypes is crucial for providing an effective treatment to the patient. For this purpose, machine learning techniques have been used in recent years...
10.
Belmonte-Reche E, Benassi A, Penalver P, Cucchiarini A, Guedin A, Mergny J, et al.
Eur J Med Chem
. 2022 Feb;
232:114183.
PMID: 35168151
Glycosyl conjugation to drugs is a strategy being used to take advantage of glucose transporters (GLUT) overexpression in cancer cells in comparison with non-cancerous cells. Its extension to the conjugation...