Jr-Shiuan Yang
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Explore the profile of Jr-Shiuan Yang including associated specialties, affiliations and a list of published articles.
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13
Citations
1173
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Recent Articles
1.
Pursell N, Gierut J, Zhou W, Dills M, Diwanji R, Gjorgjieva M, et al.
Mol Ther
. 2018 May;
26(7):1771-1782.
PMID: 29784585
Glycogen storage diseases (GSDs) of the liver are devastating disorders presenting with fasting hypoglycemia as well as hepatic glycogen and lipid accumulation, which could lead to long-term liver damage. Diet...
2.
Jee D, Yang J, Park S, Farmer D, Wen J, Chou T, et al.
Mol Cell
. 2018 Jan;
69(2):265-278.e6.
PMID: 29351846
While Slicer activity of Argonaute is central to RNAi, conserved roles of slicing in endogenous regulatory biology are less clear, especially in mammals. Biogenesis of erythroid Dicer-independent mir-451 involves Ago2...
3.
Yang J, Smibert P, Westholm J, Jee D, Maurin T, Lai E
Nucleic Acids Res
. 2013 Nov;
42(3):1987-2002.
PMID: 24220090
Although Dicer is essential for general microRNA (miRNA) biogenesis, vertebrate mir-451 is Dicer independent. Instead, its short pre-miRNA hairpin is 'sliced' by Ago2, then 3'-resected into mature miRNAs. Here, we...
4.
Smibert P, Yang J, Azzam G, Liu J, Lai E
Nat Struct Mol Biol
. 2013 May;
20(7):789-95.
PMID: 23708604
Homeostatic mechanisms regulate the abundance of several components in small-RNA pathways. We used Drosophila and mammalian systems to demonstrate a conserved homeostatic system in which the status of miRNA biogenesis...
5.
Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou Y, et al.
Development
. 2012 Jun;
139(15):2821-31.
PMID: 22745315
microRNAs (miRNAs) are endogenous short RNAs that mediate vast networks of post-transcriptional gene regulation. Although computational searches and experimental profiling provide evidence for hundreds of functional targets for individual miRNAs,...
6.
Yang J, Maurin T, Lai E
RNA
. 2012 Mar;
18(5):945-57.
PMID: 22461413
Until recently, a Dicer-class RNase III enzyme was believed to be essential for microRNA (miRNA) biogenesis in all animals. The conserved vertebrate locus mir-451 defies this expectation and instead matures...
7.
Smibert P, Bejarano F, Wang D, Garaulet D, Yang J, Martin R, et al.
RNA
. 2011 Sep;
17(11):1997-2010.
PMID: 21947201
Canonical animal microRNAs (miRNAs) are ∼22-nt regulatory RNAs generated by stepwise cleavage of primary hairpin transcripts by the Drosha and Dicer RNase III enzymes. We performed a genetic screen using...
8.
Yang J, Lai E
Mol Cell
. 2011 Sep;
43(6):892-903.
PMID: 21925378
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that generate functional microRNAs have...
9.
Yang J, Phillips M, Betel D, Mu P, Ventura A, Siepel A, et al.
RNA
. 2010 Dec;
17(2):312-26.
PMID: 21177881
An obligate intermediate during microRNA (miRNA) biogenesis is an ~22-nucleotide RNA duplex, from which the mature miRNA is preferentially incorporated into a silencing complex. Its partner miRNA* species is generally...
10.
Tsurudome K, Tsang K, Liao E, Ball R, Penney J, Yang J, et al.
Neuron
. 2010 Dec;
68(5):879-93.
PMID: 21145002
Emerging data implicate microRNAs (miRNAs) in the regulation of synaptic structure and function, but we know little about their role in the regulation of neurotransmission in presynaptic neurons. Here, we...