Josyf C Mychaleckyj
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Explore the profile of Josyf C Mychaleckyj including associated specialties, affiliations and a list of published articles.
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131
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7015
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Recent Articles
1.
Nicholas J, Raffield L, Katz D, Nicholas J, Tahir U, Katz D, et al.
Res Sq
. 2025 Feb;
PMID: 39989965
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k and Olink...
2.
Jakubek Y, Ma X, Stilp A, Yu F, Bacon J, Wong J, et al.
Am J Hum Genet
. 2025 Jan;
112(2):276-290.
PMID: 39809269
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk...
3.
Aldridge C, Keene K, Normeshie C, Mychaleckyj J, Hauck F
EBioMedicine
. 2024 Dec;
111():105484.
PMID: 39644771
Background: Sudden Infant Death Syndrome (SIDS) is a leading cause of postneonatal mortality. The absence of specific biomarkers of SIDS diagnosis and risk leaves a significant gap in understanding SIDS...
4.
Peterson T, Lima J, Shah S, Bluemke D, Bertoni A, Liu Y, et al.
ESC Heart Fail
. 2024 Sep;
12(1):239-249.
PMID: 39263947
Aims: Proteomic profiling offers an expansive approach to biomarker discovery and mechanistic hypothesis generation for LV remodelling, a critical component of heart failure (HF). We sought to identify plasma proteins...
5.
Jones A, Patki A, Srinivasasainagendra V, Hidalgo B, Tiwari H, Limdi N, et al.
Sci Rep
. 2024 Jul;
14(1):17757.
PMID: 39085340
Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic modifications, such as DNA...
6.
Jones A, Patki A, Srinivasasainagendra V, Tiwari H, Armstrong N, Chaudhary N, et al.
J Am Soc Nephrol
. 2024 Jul;
35(11):1558-1569.
PMID: 39073889
No abstract available.
7.
Mychaleckyj J, Normeshie C, Keene K, Hauck F
Am J Hum Biol
. 2024 Jul;
36(10):e24126.
PMID: 38957054
Organ weights are a possible diagnostic or pathophysiological clue to distinguishing sudden infant death syndrome (SIDS) cases from other infant deaths but suffer from major confounding. Using autopsy data from...
8.
Pugashetti J, Kim J, Bose S, Adegunsoye A, Linderholm A, Chen C, et al.
Am J Respir Crit Care Med
. 2024 Jun;
210(5):639-647.
PMID: 38843133
Accelerated biological aging has been implicated in the development of interstitial lung disease (ILD) and other diseases of aging but remains poorly understood. To identify plasma proteins that mediate the...
9.
Incident heart failure in chronic kidney disease: proteomics informs biology and risk stratification
Dubin R, Deo R, Ren Y, Wang J, Pico A, Mychaleckyj J, et al.
Eur Heart J
. 2024 May;
45(30):2752-2767.
PMID: 38757788
Background And Aims: Incident heart failure (HF) among individuals with chronic kidney disease (CKD) incurs hospitalizations that burden patients and health care systems. There are few preventative therapies, and the...
10.
Jakubek Y, Ma X, Stilp A, Yu F, Bacon J, Wong J, et al.
medRxiv
. 2024 May;
PMID: 38699360
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk...