Josue Flores-Kim
Overview
Explore the profile of Josue Flores-Kim including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
258
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0
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Recent Articles
1.
Flores-Kim J, Dobihal G, Bernhardt T, Rudner D
Elife
. 2022 May;
11.
PMID: 35593695
Penicillin and related antibiotics disrupt cell wall synthesis in bacteria causing the downstream misactivation of cell wall hydrolases called autolysins to induce cell lysis. Despite the clinical importance of this...
2.
Dobihal G, Flores-Kim J, Roney I, Wang X, Rudner D
J Bacteriol
. 2021 Dec;
204(2):e0053321.
PMID: 34871030
The WalR-WalK two component signaling system in Bacillus subtilis functions in the homeostatic control of the peptidoglycan (PG) hydrolases LytE and CwlO that are required for cell growth. When the...
3.
Nakamoto R, Kwan J, Chin J, Ong H, Flores-Kim J, Midonet C, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34732571
Many pathogenic bacteria are encased in a layer of capsular polysaccharide (CPS). This layer is important for virulence by masking surface antigens, preventing opsonophagocytosis, and avoiding mucus entrapment. The bacterial...
4.
Dobihal G, Brunet Y, Flores-Kim J, Rudner D
Elife
. 2019 Dec;
8.
PMID: 31808740
Bacterial cells are encased in a peptidoglycan (PG) exoskeleton that protects them from osmotic lysis and specifies their distinct shapes. Cell wall hydrolases are required to enlarge this covalently closed...
5.
Flores-Kim J, Dobihal G, Fenton A, Rudner D, Bernhardt T
Elife
. 2019 Apr;
8.
PMID: 30964003
Penicillin and related antibiotics disrupt cell wall synthesis to induce bacteriolysis. Lysis in response to these drugs requires the activity of cell wall hydrolases called autolysins, but how penicillins misactivate...
6.
Buss J, Baidin V, Welsh M, Flores-Kim J, Cho H, Wood B, et al.
Antimicrob Agents Chemother
. 2018 Oct;
63(1).
PMID: 30323039
New antibiotics are needed to combat the growing problem of resistant bacterial infections. An attractive avenue toward the discovery of such next-generation therapies is to identify novel inhibitors of clinically...
7.
Fenton A, Manuse S, Flores-Kim J, Garcia P, Mercy C, Grangeasse C, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(11):2812-2817.
PMID: 29487215
Most bacterial cells are surrounded by an essential cell wall composed of the net-like heteropolymer peptidoglycan (PG). Growth and division of bacteria are intimately linked to the expansion of the...
8.
Srivastava D, Moumene A, Flores-Kim J, Darwin A
mBio
. 2017 Sep;
8(5).
PMID: 28900025
The bacterial phage shock protein system (Psp) is a conserved extracytoplasmic stress response that is essential for the virulence of some pathogens, including It is induced by events that can...
9.
Flores-Kim J, Darwin A
J Bacteriol
. 2016 Oct;
198(24):3367-3378.
PMID: 27698088
Importance: The phage shock protein (Psp) response has generated widespread interest because it is linked to important phenotypes, including antibiotic resistance, biofilm formation, and virulence in a diverse group of...
10.
Flores-Kim J, Darwin A
Annu Rev Microbiol
. 2016 Jun;
70:83-101.
PMID: 27297125
The phage shock protein (Psp) system was identified as a response to phage infection in Escherichia coli, but rather than being a specific response to a phage, it detects and...